中文摘要：

细胞外信号调节激酶（ERK1/2）作为丝裂原活化蛋白激酶家族中一个重要的亚族,在调节细胞的生长、分化、应激以及死亡中起重要作用。大量研究表明,ERK信号通路在体内外心肌缺血/再灌注损伤过程中被激活并发挥了重要作用。激活ERK既可以促进细胞存活,也可以介导细胞损伤,这与细胞种类的不同或缺血/再灌注的程度及时程的不同有关。本文就ERK信号转导通路在心肌缺血再灌注损伤中的作用及其机制作一综述。

英文摘要：

It has been suggested that extra- cellular-signal regulated kinsae （ERK）, an im- portant subfamily of mitogen-activated protein kinases （MAPKs）, plays a pivotal role in modulating cell growth, differentiation, stress and death. Multiple studies showed that： during myocardial ischemia/reperfusion （I/R） injury ecr vivo and in vivo, ERK becomes activated and plays a key role in inducing cell survival or cell damage, which might be dependent on the type of cell and the degree and duration of I/R. In this review we focus on the role of ERK pathway in myocardial I/R injury.