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中文摘要：
E47是一个碱性螺旋环螺旋（BasicHelix-Loop-Helix，bHLH）蛋白，作为真核生物的一个重要转录因子，它参与了细胞周期调控，促进细胞衰老；调控胰岛素和胰高血糖素基因的转录；调节免疫细胞增生及免疫因子的合成；对骨骼肌和平滑肌的生成，以及神经系统的生成也有着重要的作用；还可诱导上皮细胞间质转型过程（EMT）致肿瘤性变化。本文就其主要功能做一综述。
英文摘要：
E47, a member of the Helix-Loop- Helix transcription factor family, has been showed to be important in eukaryotes. It was in- volved in regulating cell cycle, promoting cell senescent. E47 could regulate Insulin and Gluca- gon gene transcription, immune cells prolifera- tion and the synthesis of immune factors. In ad- dition, it not only contributed to skeletal andsmooth myogenesis, neurogenesis, but also trig- gered epithelial mesenchymal transition （ EMT ） to tumorigenicity. The main functions of E47 were summarized in this article.
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