中文摘要：

钙非依赖磷脂酶A2（iPLAz）是磷脂酶A2（PLA2）家族的一大亚族，在信号转导与磷脂重构等方面发挥重要的作用。从1900年研究胰液和蛇毒中的PLA2开始到现在已过百年，但它在生理过程中的一些重要作用直到近20年才被逐渐认识，而近15年来，越来越多的研究表明，在心肌缺血再灌时，iPLA2被激活并发挥着重要作用。本文就iPLA2做一个简介并阐述其与心肌缺血再灌注有姜柏性席与功能

英文摘要：

Calcium lipase A2 （iPLA2） is a independent phospho subfamily of phospho- lipase A2 （PLAe）, which plays an important role in signal transduction and phospholipid remode ling. Although PLA2 enzymes were first purified from cobra venom and have been known for over 100 years, only within the last 20 years has their importance in physiologic and pathologic proces ses been widely recognized. Meanwhile, overthe past 15 years, more and more studies have showed that iPLA2 was activated and played a significant role in myocardial ischemia and reper fusion （I/R）. In this review, the functional role of iPLA2 in I/R is the focus.