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中文摘要：
目的:检测生理pH值下偏端霉素衍生物与DNA间的相互作用。方法:单独的配体和DNA在300～380nm区域都没有信号,向DNA液中滴加偏端霉素衍生物,在圆二色谱(CD谱)上300～370nm区域会有信号出现。利用这种方法观察核酸构象的变化。结果:在偏端霉素衍生物与DNA的混合液的CD谱上观察到在300～370nm区域有特征峰。结论:偏端霉素衍生物对DNA的碱基有识别功能。
英文摘要：
Aim:To detect the biological activity of new synthetic distamycin derivatives,the present work gives the results of studies on the interaction between distamycin derivatives and DNA under physiological pH.Methods:Neither the free DNA nor the free ligands exhibited circular dichroism(CD)signals in the 300~380 nm wavelength region.With incremental titration of distamycin derivatives,in the CD spectra of mixed solutions a specific absorption peak will appeare in the 300~380 nm wavelength region.By this method ...
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