在微波辐射下,葡萄糖烯(1)与硝酮2环加成反应的效率大大提到,在乙二醇二甲醚溶液中,200℃封管反应2min,环加成反应产物的收率可高达96%,而且反应的立体选择性无明显变化.利用环加成产物可进一步合成各种含官能团的碳糖苷衍生物,找到了一种合成碳糖苷衍生物中间体的简便有效方法.
With microwave irradiation, the efficiency of the 1,3-dipolar cycloaddition of exo-glucal (1) with nitrones 2 was remarkably improved, and the yield of the microwave assisted reaction in a seamless pressure vial at 200 ℃ for 2 min could be up to 96%, providing a practical and convenient method for preparing spiro-isoxazolidine glycosides which are very important intermediates for synthesizing various C-glycosides possessing functional groups.