在微波促进下,利用酮糖(1)及糖酸内酯(4)与叶立德(2,Ph3P CHCOOEt)的Wittig反应,立体选择性地合成了糖基烯丙酸酯类化合物(3和5),反应效率显著提高,反应时间由原来的20 h缩短为10 min;并且研究了不同反应溶剂对反应立体选择性的影响.提供了一种高效、简便合成含有烯丙酸酯类高碳糖衍生物的方法.
In order to develop an efficient,practical and stereoselective method for synthesizing glycosyl acrylate derivatives,the microwave assisted Wittig reaction of sugar ketone(1) and lactones(4) with ylide 2(Ph 3PCHCOOEt) was investigated in a sealed microwave reactor in various temperatures and solvents.The reaction was carried out effectively and stereoselectively in xylene at 180 ℃ with a yield up to 80% within 10 min.