中文摘要：

目的：猪皮来源的细胞外基质（ECM）被广泛应用于组织工程材料的研制中，由于使用目的的不同，常需要和其它组织工程原料进行复合使用。本研究将PLGA和脱细胞猪皮进行复合，在体外考察此复合体系的力学性质和三维结构，探讨其作为组织工程支架的可行性。方法：（1）采用高压渗透法将PLGA和脱细胞猪皮制备成供检试件。（2）以扫描电镜观察其内部的三维结构。（3）用拉伸实验机测试其拉伸力学特性。结果：（1）力学测试显示，其断裂强度为1．32MPa，断裂伸长率约为132％，弹性模量为1，6×10^6Pa。（2）扫描电镜显示PLGA渗入到脱细胞猪皮的空隙中而相互融合，形成了蜂窝状结构。结论：本研究所构建的PLGA-脱细胞猪皮复合物具有适宜的机械性能。其蜂窝状结构为其作为细胞载体提供了良好的空间结构，是一种具有良好应用前景的组织工程支架。

英文摘要：

Objectives The extracellular matrix （ECM） of pigskin origin has been extensively used in the field of tissue engineering, but some times it was required to be modified by some other materials for different objectives. In this study, we fabricated a complex with PLGA ＆ acellular-pigskin, and its property of biomechanics and 3-D structure were detected. Methods （1） Samples were prepared with PLGA and acellular pigskin. （2） The microarchitecture was observed with SEM. （3） Their elongation property was tested by mechanical test machine. Results （1） Mechanical testing showed that the stress was 1.32 MPa, strain was 1.32 and the elastic modulus was 1.6× 10^6 Pa. （2） SEM observing showed PLGA has permeated into the porous-structure ofacellular pigskin to form a cellular structure. Conclusions The complex showed appropriate mechanical properties, and its cellular structure is suitable for cell adhering and migration. So, the scaffold fabricated with PLGA and acellular pigskin maybe a potential scaffold of tissue engineering.