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中文摘要：
目的研究人类白细胞抗原（HLA）配型不合造血干细胞移植治疗重型再生障碍性贫血（SAA）的疗效和安全性。方法从2006年1月至2010年5月共入选17例SAA患者接受配型不合造血干细胞移植治疗，供受者间HLA2个位点不合8例，3个位点不合9例，以改良马利兰／环磷酰胺＋抗人胸腺细胞免疫球蛋白（BU／CY＋ATG）为预处理方案，进行骨髓加外周血干细胞移植。结果所有病例均达到完全供者植入。发生Ⅲ～Ⅳ度急性移植物抗宿主病（GVHD）3例，14例可评估病例中，广泛型慢性GVHD1例；中位随访285（60～1670）d，11例患者生存，9例血象恢复正常，另2例脱离输血。6例患者死于移植相关合并症。结论当无HLA配型相合同胞供者时，SAA患者采用HLA配型不合移植是可行的治疗选择。
英文摘要：
Objective To study the efficacy and safety of human leukocyte antigen （HLA） mismatched hematopoietie stem cell transplantation （HSCT） on severe aplastic anemia （ SAA ）. Methods From January 2006 to May 2010, 17 patients received mismatched HSCT. HLA antigens were 3-loci- mismatched in 9 patients, 2-loci-mismatched in 8. All patients received recombinant human granulocyte colony-stimulating factor （rhG-CSF） primed bone marrow cells plus peripheral blood stem cells after modified busulfan/cyelophosphamide ＋ antithymocyte immunoglobulin （BU/CY ＋ ATG ） conditioning regimen. Results All patients achieved full donor type engraftment. Grade ~I-IV graft versus host disease （GVHD） occurred in 3 patients and extensive chronic GVHD in 1. With a median following-up time of 285 （60-1670） d, 11 patients were alive, 9 of them had normal blood counts and the other 2 were blood transfusion independent. Six patients died of transplant-related complications. Conclusion Mismatched HSCT is a feasible and safe option for SAA patients without sibling identical donors.
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