欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
目的探讨急性移植物抗宿主病（aGVHD）患者肝脏酶学变化与aGVHD严重程度的关系。方法回顾性分析82例发生aGVHD的患者肝脏酶学的变化情况及与aGVHD严重程度的关系。结果Ⅰ度aGVHD 15例（18．3％），Ⅱ度aGVHD 47例（57．3％），Ⅲ度aGVHD 13例（15．9％），Ⅳ度aGVHD 7例（8．5％）；ALT升高49例（59．8％），AST升高36例（43．9％），碱性磷酸酶（ALP）升高8例（9．8％）；其中34例（69．4％）患者ALT升高发生在aGVHD出现前，18例（50％）患者AST升高发生在aGVHD出现前，4例（50％）患者ALP升高发生在aGHVD出现前，ALT升高较AST升高提前出现；Ⅲ-Ⅳ度aGVHD组，ALT、AST升高的百分比（分别为80％和70％）明显高于Ⅰ～Ⅱ度aGVHD组（分别为53．2％和35．5％），但ALP升高的百分比无明显差异；Ⅲ～Ⅳ度aGVHD患者与Ⅰ～Ⅱ度aGVHD患者相比，ALT及AST峰值均明显升高；ALT升高组严重aGVHD的百分比明显升高。结论肝酶学改变在aGVHD的发生中很常见，并且与aGVHD的严重程度明显相关，肝酶学尤其是ALT可能有助于早期预警严重aGVHD的发生。
英文摘要：
Objective To investigate the correlation between the change of liver enzymes and the severity of acute graft-versus-host disease （aGVHD）. Methods The liver enzyme and severity of aGVHD in 82 patients were analyzed retrospectively. Results Among the 82 aGVHD patients, 7 developed grade Ⅰ （18.3%）, 47 grade Ⅱ （57.3%） ,13 grade Ⅲ（15.9% ） and 7 grade Ⅳ（8.5% ） aGVHD. The elevation of ALT,AST and ALP was found in 49 （ 59.8% ）, 36 （43.9%） and 8 （ 9.8% ） patients respectively. Among these patients, 34（69.4% ） were ALT 〉40 U/L, 18（50% ） AST 〉40 U/L and 4 （50%） ALP 〉 132 U/ L before the onset of aGVHD. The elevation of ALT and AST was more common and the peak value was significantly higher in patients with grade Ⅲ - Ⅳ aGVHD than with grade Ⅰ - Ⅱ aGVHD, but those of ALP showed no difference between the two groups. Compared with the patients without ALT elevation, the proportion of severe aGVHD was higher in patients with ALT elevation. Conclusions The alteration of liver enzymology is common in aGVHD and its level is correlated with the severity of aGVHD. Liver enzymes, especially the ALT, may be used as a predictor of aGVHD.
同期刊论文项目
同项目期刊论文
Effects of the NK cell recovery on outcomes of unmanipulated haploidentical blood and marrow transpl
Partially matched related donor transplantation can achieve outcomes comparable with unrelated donor
High CD4/CD8 ratio in allografts predicts adverse outcomes in unmanipulated HLA-mismatched/haploiden
First-line therapy for chronic graft-versus-host disease that includes low-dose methotrexate is asso
Expression profiles of adhesion molecules on na?ve T cells in bone marrow grafts of healthy donors t
Superior graft-versus-leukemia effect associated with transplantation of haploidentical compared wit
Expression of CD62L on donor CD4(+) T cells in allografts: correlation with graft-versus-host diseas
Characterization of CD3+CD4-CD8- (double negative) T cells reconstitution in patients following hema
Administration of short-term immunosuppressive agents after DLI reduces the incidence of DLI-associa
Immune-related late-onset hemorrhagic cystitis post allogeneic hematopoietic stem cell transplantati
Graft-versus-leukemia effects of Wilms' tumor 1 protein-specific cytotoxic T lymphocytes in patients
The inferiority of G-PB to rhG-CSF-mobilized blood and marrow grafts as a stem cell source in patien
Conflicting impact of alloreactive NK cells on transplantation outcomes after haploidentical transpl
Modified donor lymphocyte infusion (DLI) for the prophylaxis of leukemia relapse after hematopoietic
Platelet engraftment in patients with hematologic malignancies following unmanipulated haploidentica
Wilms' tumor gene 1 expression: an independent acute leukemia prognostic indicator following allogen
Immunomodulatory strategies for relapse after haploidentical hematopoietic stem cell transplantation
Monitoring MRD with flow cytometry: an effective method to predict relapse for ALL patients after al
Treating donor mice with rhIL-11 and rhG-CSF promotes transplant-tolerance and preserves the effects
The effect of HLA disparity on clinical outcome after HLA-haploidentical blood and marrow transplant
Unmanipulated HLA-mismatched/haploidentical blood and marrow hematopoietic stem cell transplantation
Individualized Intervention Guided by BCR-ABL Transcript Levels after HLA-Identical Sibling Donor Tr
Basiliximab for the treatment of steroid-refractory acute graft-versus-host disease after unmanipula
Diarrhea during the Conditioning Regimen Is Correlated with the Occurrence of Severe Acute Graft-ver
期刊信息
位置：