中文摘要：

目的：探讨人血清生长分化因子-15（GDF-15）水平上升与非ST段抬高心肌梗死（NSTEMI）后心室重构程度的相关性。方法：选择NSTEMI患者120例为NSTEMI组,另选同期体检者120例为对照组,收集临床资料,应用酶联免疫法测定血清GDF-15。于入院后96h内及随访末（12个月）行超声心动图测定左心室舒张末期容积、左室收缩末期容积、左心室射血分数等指标。分析入院时2组血清GDF-15水平变化及与NSTEMI后心室重构指标的相关性。结果：NSTEMI组血清CDF-15表达水平显著高于对照组（P〈0.01）;GDF-15与左室舒张末期容积（r=0.72,P〈0.01）、左室收缩末期容积（r=0.80,P〈0.01）、左室心肌质量（r=0.67,P〈0.01）呈正相关;与左室射血分数（r=-0.73,P〈0.01）、左室重构指数（r=-0.75,P〈0.01）呈负相关。多元线性回归分析,控制年龄、心血管危险因素及其他生化指标后,GDF-15水平仍与左室重构指数呈负相关（β=-0.821,P〈0.001）。结论：NSTEMI患者血清GDF-15表达水平升高,与NSTEMI后心室重构程度呈显著的、独立的相关性,提示GDF-15可能是预测NSTEMI后心室重构发生的可靠指标。

英文摘要：

Objective：To study the correlation between serum levels of growth differentiation factor 15 （GDF- 15） and ventricular remodeling in patients with non-ST-segment elevation myocardial infarction （NSTEMI）. Method： One hundred and twenty patients with NSTEMI as NSTEMI group and one hundred and twenty individu- als with physical examination as control group, collecte clinical data, serum levels of GDF-15 were measured by enzyme linked immunosorbent assay. The ventricular remodeling was assessed by echocardiographic within 96 hours after admission and follow-up at the end （12 months）, measuring left ventricular end-diastolic volume, left ventricular end-systolic volume, left ventricular ejection fraction and other indicators of ventricular remodeling. A- nalysis the serum levels of GDF-15 expression in two groups at admission,and its relationship with ventricular re- modeling in patients with NSTEMI. Result： The serum levels of GDF-15 in NSTEMI group was higher than that in control group （P〈0.01） The serum levels of GDF-15 related to left ventricular end-diastolic volume （r=0.72, P〈0.01）, left ventricular end-systolic volume （r=0.80,P〈0.01）, left ventricular mass index （r=0.67, P〈0.01 ） and left ventricular ejection fraction（r= --0.73, P〈0.01）, left ventricular remodeling index （r=- 0.75, P〈0.01）. The negative association between GDF-15 and LVRI remained significant in amultivariate regression model adjusted for age,cardiovascular risk factors and other biochemical parameters （standardized β=-0. 821,P d0. 001）. Conclusion： The serum levels of GDF-15 highly express in patients with NSTEMI. The serum levels of GDF-15 is independently associated with ventricular remodeling in the patients with NSTEMI, demonstrating that GDF-15 may be a reliable indicator for predicting ventricular remodeling in patients with NSTEMI.