欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
采用6-烷硫基吡啶化合物为原料，用N，N-二甲基甲酰胺（DMF）为溶剂，双氧水为氧化剂，水合钨酸钠为催化剂，经过一步氧化变成6-烷砜基多取代吡啶化合物，再在醇钠或碳酸钾的催化作用下与醇或酚反应生成含烷（芳）氧基的多取代吡啶衍生物.通过^1H NMR，EI-MS，IR，元素分析等方法对所合成的化合物进行了结构表征.代表化合物2-甲基-4-氨基-5-氰基-6-（3-硝基苯氧基）烟酸甲酯经单晶X衍射确证了结构.对合成的含6-烷（芳）氧基多取代吡啶衍生物作了初步的除草活性测试，测试结果表明：含6-烷（芳）氧基多取代吡啶衍生物对油菜和稗草具有一定的除草活性，且化合物对油菜和稗草根的抑制优于对茎的作用，表现出明显的选择性.
英文摘要：
Alkyl multisubstituted pyridine-2-yl sulfones have been designed and synthesized from 6-alkylthiopyridine using H2O2 and NaWO3·2H2O as catalysts in N,N-dimethylformamide （DMF）. A series of new 6-alkoxy（aryloxy） multisubstituted pyridine derivatives have been synthesized from alkyl multisubstituted pyridine-2-yl sulfone and alcohol or phenol using K2CO3 （NaOC2H5 or NaOCH3） as catalyst in CH3CN. The structures of target compounds have been confirmed by ^1H NMR, ^13C NMR, EI-MS, IR spectroscopy and elemental analysis. The structure of 4-amino-5-cyano-2-methyl-6-（3-nitryl phenoxy） nicotinic acid methyl ester has been determined by single crystal X-ray diffraction. The results of preliminary bioassay indicated that some compounds possess moderate herbicidal activities against the rape and barnyard grass and show obvious selectivity.
同期刊论文项目
同项目期刊论文
Synthesis and antitumor activity of novel quinazoline derivatives containing thiosemicarbazide moiet
Synthesis and herbicidal activities of potassium methyl 1-(substituted phenoxyacetoxy)alkylphosphona
Synthesis, Crystal Structure and Biological Activity of 3-(2-Chloro-4-trifluoromethylphenoxy)benzoat
The design, synthesis and biological evaluation of novel thiamin diphosphate analog inhibitors again
Synthesis and herbicidal activities of O-methyl methyl[1-(substituted phenoxyacetoxy)alkyl]phosphina
alpha-(Substituted-phenoxyacetoxy)-alpha-heterocyclylmethylphosphonates: Synthesis, Herbicidal Activ
Design, synthesis and molecular docking of amide and urea derivatives as Escherichia coli PDHc-E1 in
Synthesis, Characterization and X-ray Crystal Structure of 4-Fluoro-N-(2-methyl-5-((2-(p-tolyloxy)ac
Synthesis and Herbicidal Activities of 2-Methylpropan-2-aminium O-Methyl 1-(Substituted Phenoxyaceto
Synthesis and Herbicidal Activity of 2-(Substituted phenoxyacetoxy)alkyl-5,5-dimethyl-1,3,2-dioxapho
Synthesis and Biological Activity of O-Methyl Methyl 1-(Substituted Phenoxyacetoxy)-1-(thien-2-yl)me
Synthesis and Biological Activity of 1-(Substituted phenoxyacetoxy)1-(pyridin-2-yl or thien-2-yl) me
Synthesis, Characterization and X-ray Crystal Structure of 2-Methylpropan-2-aminium Methyl ((4-Fluor
Novel salicylamide derivatives incorporating neonicotinoid pharmacophore: design, synthesis, charact
Structural diversity-guided convenient construction of functionalized polysubstituted butenolides an
期刊信息
位置：