欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
氧化还原信号转导,尤其是蛋白质巯基的氧化性修饰,与人类许多重要疾病关系密切,是目前国际上热点研究领域之一。然而长期以来,蛋白质巯基及其氧化修饰的专一、快速检测手段缺乏,尤其是在活细胞内源性检测方面几乎是空白,限制了该领域的发展。本文就近年来用于检测蛋白质巯基及其氧化修饰的化学方法作简要综述,并就基于巯基修饰发展荧光分子探针及其用于蛋白质组学研究,氧化还原相关疾病早期诊断作一展望。
英文摘要：
Redox signal transduction,especially the oxidative modification of proein thiols,correlates with many diseases and becomes an expanding research area.However,there was rare method for quick and specific detection of protein thiols and their oxidative modification in living cells.In this article,we review the current chemical strategies for the detection and quantification of protein thiols and related cysteine oxidation.We also look into the future of the development of fluorescent probes for protein thiols and their potential application in the research of reactive cysteine proteomes and early detection of redox-related diseases.
同期刊论文项目
同项目期刊论文
A glucose-responsive controlled release system using glucose oxidase-gated mesoporous silica nanocon
A dual pH and temperature responsive polymeric fluorescent sensor and its imaging application in liv
Highly Selective Fluorescent Probe for Vicinal-Dithiol-Containing Proteins and In Situ Imaging in Li
Versatile Probes for Selective Detection of Vicinal-Dithiol-Containing Proteins (VDPs): Design, Synt
A highly selective space-folded photo-induced electron transfer fluorescent probe for carbonic anhyd
期刊信息
位置：