欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
利用生物活性亚结构拼接原理,将活性酰腙亚结构与活性噻唑环亚结构进行拼接,设计合成了14个新型N＇-芳基亚甲基-N-（4-取代苯甲酰氧基噻唑-2-基）取代苯甲酰腙衍生物.所有目标化合物经1H NMR、IR、质谱及元素分析等手段进行了表征,部分化合物还经过13C NMR进行了确证.抗肿瘤测试结果表明,该系列化合物表现出明显的抗肿瘤活性,其对人口腔上皮癌细胞株（KB）的抑制活性优于对鼻咽癌细胞株（CNE2）的抑制活性;采用离体平皿法对目标化合物进行杀菌活性测试,测试菌种为：小麦赤霉菌、水稻纹枯霉菌、黄瓜灰霉菌、番茄早疫菌、烟草赤星菌和黄瓜炭疽菌.结果表明,在1.0×10^-4 g/m L浓度下,目标化合物对部分菌种表现中等抑菌活性.
英文摘要：
14 novel N＇-arylmethylene-N-（4-benzoyloxy-thiazole-2-yl） benzoylhydrazone derivatives were designed and synthesized by incorporating the activated structural templets of thiazole and acylhydrazone. All the target compounds were characterized by 1H NMR, IR, mass spectrometry and elemental analysis, and some of the compounds were confirmed by 13 C NMR. Anti-tumor test results showed that the hydrazone compounds showed significant anti-tumor activity. These compounds were more active against the KB cell lines than the CNE2 cell lines. All synthesized compounds were screened by plate method in vitro for their fungicidal activity against Gibberella zeae, Thanatephorus cucumeris, Botrytis cinereapers, Alternaria solani, Alternaria alternate, and Colletotrichum orbiculare. In the 1.0×10^-4 g/m L concentration, some tested compounds exhibited middle-inhibitory activity of funguses.
同期刊论文项目
同项目期刊论文
Synthesis and antitumor activity of novel quinazoline derivatives containing thiosemicarbazide moiet
The asymmetric synthesis of chiral cyclic alpha-hydroxy phosphonates and quaternary cyclic alpha-hyd
Synthesis and herbicidal activities of potassium methyl 1-(substituted phenoxyacetoxy)alkylphosphona
Synthesis, Crystal Structure and Biological Activity of 3-(2-Chloro-4-trifluoromethylphenoxy)benzoat
The design, synthesis and biological evaluation of novel thiamin diphosphate analog inhibitors again
Synthesis and herbicidal activities of O-methyl methyl[1-(substituted phenoxyacetoxy)alkyl]phosphina
alpha-(Substituted-phenoxyacetoxy)-alpha-heterocyclylmethylphosphonates: Synthesis, Herbicidal Activ
Design, synthesis and molecular docking of amide and urea derivatives as Escherichia coli PDHc-E1 in
Synthesis, Characterization and X-ray Crystal Structure of 4-Fluoro-N-(2-methyl-5-((2-(p-tolyloxy)ac
Synthesis and Herbicidal Activities of 2-Methylpropan-2-aminium O-Methyl 1-(Substituted Phenoxyaceto
Synthesis and Herbicidal Activity of 2-(Substituted phenoxyacetoxy)alkyl-5,5-dimethyl-1,3,2-dioxapho
Synthesis and Biological Activity of O-Methyl Methyl 1-(Substituted Phenoxyacetoxy)-1-(thien-2-yl)me
Synthesis and Biological Activity of 1-(Substituted phenoxyacetoxy)1-(pyridin-2-yl or thien-2-yl) me
Synthesis, Characterization and X-ray Crystal Structure of 2-Methylpropan-2-aminium Methyl ((4-Fluor
Novel salicylamide derivatives incorporating neonicotinoid pharmacophore: design, synthesis, charact
期刊信息
位置：