欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
为了研究O-烷基α-（取代苯氧乙酰氧基）烃基膦酸衍生物的结构活性关系，以取代苯氧乙酸为起始原料，经氯化亚砜氯化后得中间体2，然后与不同取代的α-羟基烃基膦酸酯（（1））反应制备关键中间体3，再与碘化钠或溴化锂反应，合成了14个未见文献报道的O-烷基α-（取代苯氧乙酰氧基）烃基膦酸盐4. 通过1H NMR，IR，MS和元素分析对所合成的化合物进行了结构表征. 初步的生物活性测试结果表明：大多数目标化合物具有较好的除草活性或杀菌活性. 化合物4a在1.5 kg/ha剂量下对所测单、双子叶植物的抑制率均达到了100%；在50 μg/g的剂量下，化合物4h～4m对油菜菌核菌和黄瓜灰霉菌的抑制率达到90%以上.
英文摘要：
For the purpose of studying the structure-activity relationship of O-alkyl α-（substituted phenoxyacetoxy）alkylphosphonic derivatives, fourteen novel O-alkyl α-（substituted phenoxyacetoxy）alkylphosphonates were synthesized by the reactions of key intermediate 3 with NaI or LiBr. The intermediate 3 was prepared by the treatment of α-hydroxyalkylphosphonates 1 with substituted phenoxyacetyl chlorides 2 which could be easily obtained by the reaction of substituted phenoxyacetic acids with excess thionyl chloride. The structures of compounds 4 have been confirmed by 1H NMR, IR, MS and elemental analyses. The results of preliminary bioassay indicated that most of title compounds possess significant herbicidal and fungicidal activities. Compound 4a showed 100% inhibitory activity against all the tested species in the rate of 1.5 kg/ha. Compounds 4h～4m exhibited more than 90% inhibitory activity against Sclerotinia sclerotiorum and Botrytis cinerea in the rate of 50 μg/g.
同期刊论文项目
同项目期刊论文
Synthesis and antitumor activity of novel quinazoline derivatives containing thiosemicarbazide moiet
The asymmetric synthesis of chiral cyclic alpha-hydroxy phosphonates and quaternary cyclic alpha-hyd
Synthesis and herbicidal activities of potassium methyl 1-(substituted phenoxyacetoxy)alkylphosphona
Synthesis, Crystal Structure and Biological Activity of 3-(2-Chloro-4-trifluoromethylphenoxy)benzoat
The design, synthesis and biological evaluation of novel thiamin diphosphate analog inhibitors again
Synthesis and herbicidal activities of O-methyl methyl[1-(substituted phenoxyacetoxy)alkyl]phosphina
alpha-(Substituted-phenoxyacetoxy)-alpha-heterocyclylmethylphosphonates: Synthesis, Herbicidal Activ
Design, synthesis and molecular docking of amide and urea derivatives as Escherichia coli PDHc-E1 in
Synthesis, Characterization and X-ray Crystal Structure of 4-Fluoro-N-(2-methyl-5-((2-(p-tolyloxy)ac
Synthesis and Herbicidal Activities of 2-Methylpropan-2-aminium O-Methyl 1-(Substituted Phenoxyaceto
Synthesis and Herbicidal Activity of 2-(Substituted phenoxyacetoxy)alkyl-5,5-dimethyl-1,3,2-dioxapho
Synthesis and Biological Activity of O-Methyl Methyl 1-(Substituted Phenoxyacetoxy)-1-(thien-2-yl)me
Synthesis and Biological Activity of 1-(Substituted phenoxyacetoxy)1-(pyridin-2-yl or thien-2-yl) me
期刊信息
位置：