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中文摘要：
目的：测定20名中国男性健康受试者口服复方新诺明片（含磺胺甲恶唑800mg)后磺胺甲恶唑（SMZ）和N^4-乙酰基-磺胺甲恶唑（N^4-Ac-SMZ)的血药物浓度，进行药代动力学研究。方法：用反相高效液相色谱法同时测定磺胺甲恶唑和N^4-乙酰基-磺胺甲恶唑的血浆浓度，并计算药代动力学参数。结果：磺胺甲恶唑和N^4-乙酰基-磺胺甲恶唑的tmax分别为1.83±0.71h和8.10±2.94h,Cmax分别为37.57±13.52mg·L^-1和5.89±2.90mg·L^-1,t1/2分别为10.25±1.16h和12.65±1.44h,AUC0-34h分别为486.0±183.6mg·h·L^-1和131.7±64.1mg·h·L^-1,AUC0-8分别为562.6±196.7mg·h·L^-1和162.2±82.9mg·h·L^-1，MRT分别为15.8±1.5h和21.9±1.9h。结论：磺胺甲恶唑的乙酰化代谢途径为生成限速代谢模式，20人中没有发现明显的快慢代谢分型。
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