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中文摘要：
临床上广泛使用的（Ｅ）－罗红霉素在人体内有多种代谢途径。在鉴别和制备其代谢产物的基础上，采用二倍稀释法，选用３种生物检测实验标准菌株，测定了母体药物和６种主要代谢产物的体外抗菌活性（ＭＩＣ，ＭＢＣ）。结果表明，（Ｅ）－罗红霉素经代谢转化后，生成的（Ｚ）－罗红霉素异构体的活性略下降，（Ｅ）－红霉素肟的活性无明显改变，（Ｅ）－Ｏ－单去甲罗红霉素的ＭＩＣ未改变，而对芽孢杆菌的ＭＢＣ有所降低，（Ｅ）－Ｎ－单去甲甲红霉素的活性显著降低，（Ｅ）－脱红霉糖罗红霉素则基本失活， 药物及代谢物在不同菌株之间的ＭＩＣ和ＭＢＣ变化趋势基本相同，ＭＢＣ较相应的ＭＩＣ大１００～１０００倍左右。
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