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生物质谱技术应用及进展
  • 期刊名称：军事医学科学院院刊
  • 时间：0
  • 页码：24: 146, 2000
  • 语言：英文
  • 相关项目：创新药物相关的药物代谢与动力学基础理论和新方法研究
作者： 应万涛|钱小红|
同期刊论文项目
创新药物相关的药物代谢与动力学基础理论和新方法研究
期刊论文 129 会议论文 63 著作 9
同项目期刊论文
Determination of simvastatin in human plasma by LC/MS/MS: application to the PK study in healthy Chi
短刺小克银汉霉菌对维拉帕米转化的能力
LC/MS/MS法测定人血浆中地洛他定：在药代动力学研究中的应用
液相色谱(电喷雾串联质谱法测定血浆中克仑特罗
西地那非衍生物的电喷雾离子阱质谱研究
阿苯达唑硫氧化产物的合成及电喷雾质谱分析
液相色谱(质谱(质谱联用法快速测定人血浆中法莫替丁含量
萘普生的微生物转化
高效液相色谱梯度洗脱法测定大鼠胆汁中9-硝基喜树碱含量
液相色谱(质谱联用法测定牛奶中4种四环素类药物残留量
拟低聚氨基糖类系列化合物异戊他定的微生物转化
柱前手性衍生化(正相高效液相色谱法拆分甲基麻黄碱对映异构体
重组蛋白多肽的临床药代动力学
Profiling of isovalertatin family aminooligosaccharides extracted from the culture of Streptomyces l
液相色谱(电喷雾串联质谱法测定人血浆中的班布特罗：在药物动力学研究中的应用
固相萃取(液相色谱(串联质谱法快速分析血浆中特布他林
美洛昔康在中国健康受试者体内的药物动力学研究
柱前衍生化(反相高效液相色谱法拆分酮洛芬对映异构体
麻黄碱对映异构体的柱前手性衍生化(反相高效液相色谱法拆分
6种口服降糖药的液相色谱(质谱分析
Identification of the metabolites of roxithromycin in humans
Simultaneous determination of flupirtine and a major active metabolite in human plasma by LC/MS/MS
Quantitative determination of nitrendipine and its metabolite in human plasma using LC/MS/MS
Demethylation metabolism of roxithromycin in humans and rats
重组人血小板生成素(rhTPO)在小鼠体内的代谢、分布和排泄
储存磷光屏放射自显影测定兔血浆中125I-重组人尿激酶原浓度的应用
氨基酸组成分析直接鉴定SDS-PAGE分离的蛋白质
Structural revision of isovalertatin M03, M13, and M23 isolated from the culture of Streptomyces lut
毛细管区带电泳监测牛胰岛素的去折叠过程
Determination of free and total wogonin in rat plasma by LC/MS/MS
Selective biotransformation of propafenone by Cunninghamella blakesleana
液相色谱-质谱-质谱联用法测定人血浆中氨氯地平
利用微生物转化模型研究苯丙哌林的代谢产物
大学生维生素C稳态血浆浓度分析
释放分割法体外评价释放特征符合Higuchi方程的缓释制剂药物动力学
愈美分散片人体药动学及制剂生物等效性研究
液相色谱(质谱联用法检测体液中三唑仑及其代谢产物
液相色谱(串联质谱法测定人血浆中的伪麻黄碱浓度
氨氯地平在中国受试者体内的药物动力学及制剂的生物等效性
用高效液相色谱方法测定人血浆中美洛昔康浓度
双硫仑的化学稳定性及降解产物
用液相色谱(离子阱质谱联用法检测兔体液中阿普唑仑及其主要代谢物
磺胺甲噁唑及其乙酰化代谢物的药代动力学研究
采用微生物转化法合成5-羟基普萘洛尔
罗红霉素主要代谢产物的体外抗菌活性研究
猕猴多次皮下注射重组人血小板生成素后药代动力学、血小板计数和抗体的变化
MALDI-TOF-MS研究糖蛋白核糖核酸酶B的一级结构
重组蛋白多肽药物生物等效性研究的必要性、可行性和方法学
重组人肿瘤坏死因子(突变体11a 的I期临床药代动力学
基因重组人粒-巨噬细胞集落刺激因子/白细胞介素-3融合蛋白在猕猴中的药代动力学
人尿源性激肽释放酶在家兔和大鼠中的药代动力学
单链尿激酶型纤溶酶原激活剂在兔和猕猴中的生物转化和药代动力学
静注125I-标记人重组单链尿型纤溶酶原激活剂后酸可沉淀放射性在兔组织的分布
MALDI-TOF-MS分析基因重组糖蛋白rhEPO的一级结构
Structural revision of isovalertatin D03 and D23 isolated from the culture filtrate of Streptomyces
Studies of the abnormal bioavailability of clarithromycin and in vitro QC
Applications of LC/MS/MS in drug and biomedical analyses
Two butylated aminooligosaccharides isolated from the culture filtrate of Streptomyces luteogriseus
Study of the electrospray ionization tandem mass spectrometry of sildenafil derivatives
液相色谱(光谱联用技术在天然产物化学筛选中的应用
液相色谱(串联质谱法测定大鼠血浆中的汉黄芩素
LC/MSn法同时检测人尿中艾司唑仑、阿普唑仑和三唑仑
新型抗炎镇痛剂SFZ-47在家兔体内主要代谢产物的分离与鉴定
生物质谱技术在糖蛋白结构分析中的应用
兔体内乌头碱代谢产物研究
猕猴静脉推注加滴注重组人碱性成纤维细胞生长因子后的药代动力学
Quantitation of the flavonoid wogonin and its major metabolite glucuronide in rat plasma by LC/MS/MS
Isolation and identification of the glucuronide of 4-(3H-1,2-dihydro-1- pyrrolizinone-2-methylamino)
Sensitive and specific LC/MS/MS assay for dihydroergotamine and its major metabolite in human plasma
Metabolism of roxithromycin in phenobarbital-treated rat liver microsomes
西地那非哌啶衍生物的负离子电喷雾多级质谱研究
新型抗炎镇痛剂SFZ-47及其代谢物的电喷雾离子阱质谱研究
Pharmacokinetics and partial thrombo- plastin time after intra-venous recom- binant hirudin variant-
乙氧苯柳胺-2-葡糖苷酸的分离鉴定
BE study of amlodipine maleate tablet and amlodipine besylate tablet (Norvasc) in healthy Chinese su
PK of a sustained-release formulation of buflomedil after single and multiple doses in healthy Chine
etermination of carbocysteine in human plasma by LC/MS/MS employing precolumn derivatization
生物质谱结合IMAC亲和提取和磷酸酶水解分析蛋白质磷酸化修饰
The metabolism of roxithromycin in golden hamsters
乙肝核酸疫苗在ＢＡＬＢ/ｃ小鼠体内的生物分布情况
液相色谱(串联质谱法同时测定人血浆中伪麻黄碱和苯海拉明
Identification of the metabolites of 9-nitro-20(S)- camptothecin in rats
A novel metabolic pathway of morphine: formation of morphine glucosides in cancer patients
Determination of ketotifen and its conjugated metabolite in human plasma by LC/MS/MS: application to
Determination of three major components of bitespiramycin and their major active metabolites in rat
Determination of scutellarin in rat plasma by HPLC/UV detection
Determination of cefaclor in human plasma by a sensitive and specific LC/MS/MS method
Pharmacokinetics of loratadine and its active metabolite in healthy Chinese subjects
Metabolism of SFZ-47 in chicken embryo by LC/MSn.
Microbial transformation of naproxen by Cunninghamella species
Pharmacokinetics of 9-nitro-20(S)- camptothecin in rats
LC-MS-MS analysis of 2-pyridylacetic acid: application to a pharmacokinetic study in healthy volunte
电喷雾-串联四极杆-飞行时间质谱法分析寡肽的一级结构
亲和层析结合生物质谱鉴定猕猴血清中的重组人内皮抑制素
Multiplex Single Nucleotide Polymorphisms Genotyping by MALDI-TOF Mass Spectrometry
大鼠硬膜外和静脉注射虎纹毒素-I后的组织分布
Pharmacokinetics of a novel antibiotic bitespiramycin in rats
液相色谱(质谱(质谱联用法测定猕猴血浆中阿德福韦
Quantitation of plasma samples with LC/MS/MS: application in PK studies
Ion suppression effects in pharmacokinetic assay by LC/MS/MS
Identification of drug metabolites with liquid chromatography(ion trap MS
Metabolism and absorption of epidermal growth factor (EGF) in rat’s in situ stomach and intestine
猕猴硬膜外及静脉注射 [~(125)I]虎纹毒素-1的药代动力学
罗红霉素在犬体内的代谢转化
高效液相色谱法测定大鼠组织及血浆中9-硝基喜树碱含量
LC/MS/MS法测定人血浆中非那雄胺的浓度及其药代动力学研究
液相色谱-质谱联用法鉴定必特螺旋霉素中多组分
HPLC法测定复方片剂中依那普利相关物质
In vitro identification of metabolites of verapamil in rat liver microsomes
Metabolites of a novel antibiotic bitespiramycin in rat urine and bile
Biotransformation of verapamil by Cunninghamella blakesleana
Anti-tussive activity of benproperine enantiomers on citric acid-induced cough in conscious guinea p
Rearrangement process occurring in the fragmentation of adefovir derivatives
Simultaneous determination of albendazol and its major active metabolite in human plasma using LC/MS
LC/MS/MS测定人血浆中氯诺昔康：在药物动力学研究中的应用
头孢克洛缓释片临床药代动力学及生物等效性
LC/MS/MS法测定比格犬血浆中特拉唑嗪及其在PK研究中的应用
(1-酸糖蛋白手性柱拆分泮托拉唑对映体
Rapid determination of metformin in human plasma by LC/MS/MS
Determination of nimodipine in human plasma by a sensitive and specific LC/MS/MS
Simultaneous determination of chlorpheniramine and pseudoephedrine in human plasma by LC/MS/MS
pH-Dependent geometric isomerization of roxithromycin in simulated gastrointestinal fluids and in ra
^125I-聚乙二醇化胸腺素α1的制备与纯化
α1—酸糖蛋白手性柱拆分泮托拉唑对映体
LC／MS／MS法测定比格犬血浆中特拉唑嗪及其在药物动力学研究中的应用
液相色谱-电喷雾串联质谱法测定血浆中二氢麦角胺及其8'-羟基代谢物
小克银汉霉菌对萘普生的微生物转化(英文)
人与大鼠体内罗红霉素去甲基化代谢(英文)