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中文摘要：
目的：建立泮托拉唑对映体拆分和对映体光学纯度测定方法。方法：用α1-酸糖蛋白手性固定相，考察了缓冲液的种类和pH、有机改性剂的种类和比例、流速及柱温对泮托拉唑对映体拆分的影响。采用Chiral—AGP柱(150mm×4．6mm,5μm，配有手性AGP预柱)，以10mmol·L^-1醋酸铵缓冲液(pH5．5)—乙腈(93：7)为流动相，在流速为0．9mL·min^-1，检测波长为290nm，柱温为20℃的条件下拆分泮托拉唑对映体。结果：用α1-酸糖蛋白手性固定相能完全分离泮托拉唑对映体，分离度达1．77，并测定了泮托拉唑对映体过量百分率。结论：流动相pH和有机改性剂含量是影响对映体分离的重要因素，可以以调节流速和柱温来提高柱效、改善分离。
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