中文摘要：

用磷脂酰乙醇胺（DEPE）、鞘磷脂（Sphingomyeline，Sph）、神经节苷脂（Gml）和胆固醇（Chol）模拟了生物膜超分子体系液晶态结构，通过用小角X射线衍射（SAXD）对混合脂体系液晶态结构进行了研究，鉴定出了两种立方相：即Im3m（Q^229）和Pn3m（Q^224）结构．实验发现，鞘磷脂的含量对DEPE膜的结构有一定的影响，随着鞘磷脂浓度的增加，混合脂体系的液晶态结构发生了由胁3m（Q^229）到Pn3m（Q^224）的变化．神经节苷脂（Gml）的含量对混合脂体系的液晶态结构也有一定的影响，当神经节苷脂（Gml）含量达到某一临界值时，混合脂体系的液晶态结构发生了从Im3m（Q^229）到Pn3m（Q^224）的变化．当DEPE—Shp-Gml超分子聚集体中含有胆固醇时，胆固醇的极性头部（-OH）与磷脂酰乙醇胺（DEPE）、鞘磷脂（Shp）、神经节苷脂（Gml）的极性头部通过氢键相互作用形成液晶态立方相Im3m（Q^229）结构，再通过疏水／亲水相互作用形成稳定的Pn3m（Q^224）结构．

英文摘要：

It has been investigated that the super-molecular structures in liquid crystalline states are made up of DEPE （1,2-dielaidoyl-sn-glycero-3-phosphatidyl-ethanolamine）, sphingomyeline, monosialiogan- glioside-Gml and cholesterol by small angle X-ray diffraction. The effect of sphingomyeline on DEPE film was determined. A structure transition from Im3m（Q^229） to Pn3m（Q^224） occurred with increasing sphingomyeline concentration in the super-molecular structures. The effect of monosialioganglioside-Gml content on the super-molecular structures was also determined. At a critical concentration of monosialioganglioside-Gml, the structure transition from Im3m（Q^229） to Pn3m（Q^224） occurred. The effect of the addition of cholesterol on DEPE-Shp-Gml super-molecular structure has also been investigated. There exists an interaction between the polar head （-OH） of cholesterol and that of DEPE, sphingomyeline, monosialioganglioside-Gml by oxygen-halogen bond, to form cubic phase of liquid crystalline states. A Pn3m（Q^224） structure was further formed by hydrophilic/hydrophobic interaction.