中文摘要：

目的：探讨温热药治疗虚寒证的分子机制。方法：选择1对虚寒证兄妹，用温热药（麻辛附子汤合金匮肾气丸加减）治疗45d，采有显效妹妹的外周血进行基因芯片实验，应用倍数分析方法进行数据处理，并对结果进行基因功能分类、通路分析等信息挖掘。结果：初步获得276条差异表达基因，与新陈代谢基因密切相关，涉及18条通路。结论：温热药主要影响了代谢基因的表达，疗效与证候的基因表达谱存在明显差异，温热药可能是通过基因网络发挥治疗作用的。

英文摘要：

Objective： To study the therapeutic molecular mechanism of the warm-hot drugs treating cold syndrome. Method： A brother and his sister with deficiency-cold syndrome were chosen and treated with appropriate Chinese formula consisted chiefly of warm-hot drugs for 45 days. Then microarray technique was applied for comparing the gene expression difference of sister who had significant effect, the data was dialed with multiple analysis method and the results were mined though gene function and pathway. Results： 276 differential genes were obtained, which were related to metabolism and 18 pathways. Conclusion： Warm-hot drugs work on the gene expression of metabolism. It may be exerting the curative action by gene network and there is distinct difference between gene expression of curative effect and syndrome.