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中文摘要：
通过分析不同给药剂量硝酸钕[Nd（NO3）3][2，10，50mg／kg（体重）]后，雄性Wistar大鼠完整肝组织的MAS1HNMR谱和肝组织提取物的^1H NMR谱，结合肝组织病理切片图，研究了稀土化合物Nd（NO3）3在大鼠体内的急性生物效应．利用模式识别方法对给药Nd（NO3）3组和对照组大鼠肝组织^1H NMR谱图数据进行了分析．结果表明，腹腔注射Nd（NO3）3后，大鼠肝脏中甘油三酯、亮氨酸（异亮氨酸）、乳酸、丙氨酸、丙酮酸、磷酸胆碱和葡萄糖含量升高，氮氧三甲胺含量降低．肝脏病理图显示，50mg／kg（体重）组大鼠肝细胞可见微小坏死灶和门管区炎细胞轻度增多．推测硝酸钕能影响大鼠肝脏中能量代谢（糖代谢和脂肪代谢）和氨基酸代谢，对大鼠肝脏造成损伤，且其损伤程度随剂量的增加有增强趋势．
英文摘要：
The biochemical effects of neodymium nitrate were studied by NMR spectroscopic-based metabonomic approach. Male Wistar rats were treated intraperitoneally with different doses （2, 10 and 50 mg/kg body weight） of Nd（ NO3 ）3. Liver samples from Nd^3＋ -treated rats were analyzed either by 600 MHz ^1H MAS NMR techniques for intact liver or using high resolution （liquid state） ^1H NMR for liver chloroform/water/methanol extracts. All NMR spectra data were analyzed by pattern recognition using principal components analysis. Liver lesions induced by Nd （NO3 ）3 were represented by increased triglyceride, leucine （isoleucine）, lactate, alanine, pyruvate, phosphocholine and glucose concentration, and reduced trimethylamine N-oxide （TMAO） concentration in liver. Histopathology examination showed cell necrosis and inflammation in the liver of 50 mg/kg body weight dosed rats. It was demonstrated that neodymium nitrate could cause damages to rats liver by disturbing the energy metabolism（ glucose and lipid metabolism） and amino acid metabolism in the liver.
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