中文摘要：

近几年来,在稀土农用安全性的争议尚未彻底解决之际,其作为诊疗药物使用的安全性问题又成为研究的焦点。本文从细胞无机化学的角度,提出了其中几个关键问题,并从下面几方面进行了分析讨论。第一,生物体系中的固相形成和沉积的作用。因为在研究稀土的生物效应以及解释其有关临床病理表现时,均会涉及到难溶化合物的形成、转化以及分布和调控;第二,在正常和病理条件下,稀土化合物的吸收、排出与积累问题,尤其是稀土跨血-组织屏障的问题,这也是关于稀土是否产生毒性的争论焦点;第三,从相似/相异性规律出发,探讨了稀土元素引起生物效应的共性和特性;第四,讨论了稀土化合物促进细胞增殖凋亡的信号转导机制以及所引发的问题。并在此基础上,提出了在细胞层次研究金属离子及配合物的生物效应时所面临的关键问题。

英文摘要：

The controversy about the safety issue concerning the agricultural application of lanthanides（Ln） has not yet been completely resolved. In recent years, the scientific basis of the safety in relation to their uses as diagnostic agents and potential drugs has become the research focus. This review proposed several related critical problems in view of the cellular inorganic chemistry and discussed them from the following aspects. First, the role of the solid-phase formation and deposition in biological systems, as in the study of the biological effects of Ln, as well as elucidation of their performance on the clinical pathology, the formation, transformation, distribution and modulation of insoluble compounds have always been involved. Second, issues on the absorption, excretion and accumulation of Ln, especially on whether Ln cross the blood-tissue barriers, it is one of the foci of debate over their toxicity. Third, in the light of the similarity/dissimilarity principle, the common and specific characteristics of biological effects induced by Ln elements have been discussed. Fourth, the signaling pathways involved in the Ln-promoted cell proliferation and apoptosis, as well as the arising problems have been discussed. Based on the above discussions, the key issues faced by the cellular and biological studies on the metal ions or metal-based compounds have been proposed.