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中文摘要：
采用现代核磁共振和模式识别技术,分析了腹腔注射给药2、10和50mg/kg体重剂量硝酸钕48h内Wistar大鼠尿液和血清的核磁共振氢谱。由尿液及血清中内源性代谢物如柠檬酸、肌酸酐、N-氧三甲胺、氨基酸、乳酸、琥珀酸、牛磺酸及葡萄糖等物种的浓度变化,结合大鼠血清指标和肝、肾组织切片图研究了轻稀土化合物Nd（NO3）3在大鼠体内的急性生物效应。结果表明,3个剂量的Nd（NO3）3主要对大鼠肝脏造成了不同程度的损伤,而且随着剂量的升高渐趋严重。同时,Nd（NO3）3也对肾脏的特定部位（肾乳头、肾小管）造成了损害。
英文摘要：
The biochemical effects of Nd （ NO3 ） 3 was studied by NMR-based metabonomics. Male Wistar rats were administrated intraperitoneally with Nd（ NO3 ）3 at doses of 2, 10 and 50 mg/kg body weight. Urine was collected over a 48-h period after dosing and serum was collected after 48 h. ^1H NMR spectra of biofluids （urine and serum） were analyzed by pattern recognition using principal components analysis. The studies showed that there was a dose-related biochemical effects of Nd（ NO3 ）3 treatment. The liver and kidney （renal tubular and renal papilla） damage induced by Nd（ NO3 ）3 was characterized by the variations of many endoge- nous metabolites, such as citrate, creatinine, N-trimethyl dioxide, dimethyl amine, dimethyl glycine, lactate, taurine and glucose. The NMR-based metabonomics can be applied to study the biochemical effects or toxicities of other compounds.
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