中文摘要：

以D-（＋）-二苯甲酰酒石酸（D-（＋）-DBTA）为流动载体,研究了克伦特罗（clenbuterol,Cle）对映体的厚体液膜法拆分,建立了手性拆分条件和动力学拆分模型。考察了D-（＋）-DBTA浓度、缓冲液pH值对手性拆分性能的影响,进行了动力学分析,并测定了膜-料液界面的萃取反应表观速率常数k1和膜-反萃相界面的反萃取表观速率常数k2。结果表明：在优化的实验条件下（pH为7,手性载体与Cle浓度比为1∶4）,Cle外消旋体能被含有手性载体D-（＋）-DBTA的厚体液膜有效拆分,分离因子大于1.08;Cle单体的跨膜迁移过程可以用两个串联的准一级不可逆过程进行描述。

英文摘要：

Bulk liquid membrane （BLM） containing D-（ ＋ ）-dibenzoyhartaric acid （D-（ ＋ ）-DBTA） as chiral carrier was used for the resolution of racemic clenbuterol, the optimal chiral extraction conditions and the kinetic resolution model were established. The influences of the molar concentration of chiral mobile carrier and pH in aqueous phase on chiral resolution performance were investigated. The chiral resolution of BLM was analysed by means of a kinetic model involving two consecutive irreversible first order reactions. The pseudofirst order apparent rate constants, k1 and k2, of interfacial reactions in membrane-feed solution interface or membrane-stripping solution interface were determined. The results show that under the optimal conditions （pH 7, the molar concentration ratio of D-（ ＋ ）-DBTA： cleubuterol = 1：4）, clenbuterol enantiomer can be enantioseparated effectively by BLM containing D-（ ＋ ） -DBTA, the separation factor of clenbuterol enantiomer is more than 1.08; the kinetic resolution of clenbuterol can be evaluated by two consecutive irreversible first order reactions.