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中文摘要：
目的探讨超顺磁性氧化铁（SPIO）联合钆剂（Gd-DTPA）增强对诱发大鼠肝硬化肝癌结节的诊断价值。方法Wistar大鼠50只（实验组n=40,对照组n=10）,前者饮水中加入二乙基亚硝胺到第12周,第13～19周随机抽取大鼠进行SPIO联合Gd-DTPA增强扫描,取大于3mm结节送病理,区分肝硬化（RNs）和肝癌（HCC）结节;比较两种对比剂增强的肿瘤检出率,结果进行χ^2检验。结果106个结节中RNs24个,HCC82个,SPIO、Gd-DTPA增强肿瘤检出率分别为95.12%、89.02%,SPIO肿瘤检出率高于Gad-DTPA（P〉0.05）。结论SPIO较Gd-DTPA增强更易检出肝癌结节,SPIO联合Gad-DTPA增强对肝硬化、肝癌结节定性诊断有互补作用。
英文摘要：
Objective To investigate the value of superparamagnetic iron oxide （SPIO） and Gd-DTPA Enhanced MR imaging in diagnosis of regenerative nodules and hepatocellular carcinoma （HCC） in rat model. Methods Fifty Wistar rats were divided into two groups., treated group （40 rats） and control group （10 rats）. For the rats in the first group 0. 01 mg DEN were added into every 100 ml drinking water till week 12. From week 13 to week 19, the rats were randomly chosen and scanned by using SPIO and Gd-DTPA for Enhanced MR imaging. Chose the nodules diameter〉3 mm for pathologic inspection, distinguished RNs from HCC. Tumor detection rate of SPIO and Gd-DTPA was Compared,the difference was analyzed by chi square test. Results RNs（n=24） ,HCC （n=82） in 106 nodules. Tumor detection rate of SPIO and Gd-DTPA Enhanced MR imaging was 95.12%, 89.02%, respectively. Detection rate of SPIO was higher than Gd-DTPA （P〉0.05）. Conclusion SPIO MR imaging can improve the detectability of HCC; SPIO combining Gd-DTPA enhanced MR imaging is compensatory for differentiating RNs from HCC.
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