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自制解郁汤联合氟西汀治疗抑郁症效果观察

ISSN号：2095-140X
期刊名称：《解放军医药杂志》
时间：0
分类：R749.4[医药卫生—神经病学与精神病学;医药卫生—临床医学]
作者机构：[1]解放军总后勤部卫生部科训局,北京100842, [2]解放军261医院生物诊疗中心,北京100094, [3]心理危机干预中心, [4]门诊部
相关基金：首都医学发展基金重点支持项目（SF-2007-Ⅱ-04）

关键词：抑郁症, 自制解郁汤, 氟西汀, 治疗结果, Depressive disorder, Self-made recieving decotion, Fluoxetine, Treatment outcome

中文摘要：

目的观察自制解郁汤联合氟西汀治疗抑郁症的效果。方法84例抑郁症随机分为观察组和对照组各42例，对照组采用氟西汀治疗，观察组在对照组基础上联合自制解郁汤治疗，两组疗程均为8周，采用汉密尔顿抑郁量表（HAMD）评定临床疗效，应用治疗意外症状量表（TESS）评定不良反应，随访3年观察复发率。结果观察组痊愈率和总有效率均高于对照组，治疗8周末两组HAMD评分均低于治疗前，观察组治疗后2、4、6、8周末HAMD评分均低于对照组（P〈0．01，P〈0．05）。对照组发生不良反应53例次，观察组仅发生12例次。随访3年，观察组复发率低于对照组，差异有统计学意义（P〈0．05）。结论自制解郁汤联合氟西汀治疗抑郁症效果好、复发率低。

英文摘要：

Objective To observe the efficacy of self-made relieving depression decoction combined with fluoxe- tine in treatment of depression. Methods A total of 84 patients with depression were randomly divided into two groups （n = 42）： observation group with self-made Chinese medical herb -relieving depression decoction combined with fluoxe- tine, and control group with fluoxetine only. All patients were treated for 8 weeks. The efficacy was evaluated with Hamil- ton Depression Scale （HAMD） and adverse reaction was evaluated with Treatment Emergent Symptom Scale （TESS）. Recurrence rates with 3 years of follow-up were calculated. Results The cure rate and total efficacy rate in observation group was significantly higher than those in control group. The scores of HAMD after treatment at the end of 8 weeks in both groups were significantly lower than those before treatment. And the scores of HAMD in observation group were sig- nificantly lower than those in control group after treatment at the end of 2, 4, 6 and 8 weeks（ P 〈 0.01 ,P 〈 0.05 ）. The frequencies of adverse reaction were 53 times in control group, and 12 times in observation group. The recurrence rate in observation group was significantly lower than that in control group during 3-years follow-up （ P 〈 0.05 ）. Conclusion The method of self-made relieving depression decoction combined with fluoxetine in treatment of depression may have bet- ter effect and low recurrence rate.

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