中文摘要：

瞄准：在肿瘤在 chemoembolization 以后在散开加权的成像(DWI ) 上建模的兔子 VX-2 调查动态特征和信号的病理学的机制。方法：四十只新西兰兔子在学习被包括，在腹的洞开了以后， 47 个兔子 VX-2 肿瘤模特儿被直接并且 intrahepatically 植入抚养。从他们的四十个 VX-2 肿瘤模型被划分成四个组。DWI 在 chemoembolization 以后为每个组周期性地并且分别地被执行。每个组的所有 VX-2 肿瘤样品被病理学习。DWI 上的 VX-2 肿瘤的区别被他们的明显的散开系数(模数转换器) 估计价值。在不同时间组，不同区域组或不同 b 值组之间的统计意义被使用 SPSS12.0 软件计算。结果：在 100 s/mm2 的 b 值下面，模数转换器价值在在在 VX-2 肿瘤圆周的区域的 chemoembolization 以后的 16 h 是最低的，在肿瘤附近的中央、正常的肝实质，但是转弯了与 chemoembolization 处理的进一步的延伸增加。在不同时间组之间的模数转换器的区别分别地是重要的(F = 7.325， P 【 0.001；F = 2.496， P 【 0.048；F = 6.856， P 【 0.001 ) 。在在肿瘤附近的 VX-2 肿瘤圆周或正常肝实质的区域的细胞的浮肿，在 chemoembolization 以后在十六 h 快速增加了但是，从 第16 h 到 第48 h ，在在肿瘤附近的正常肝实质的区域的细胞的浮肿逐渐地减少了，那轻轻地在 VX-2 肿瘤圆周的区域减少了在，然后不断地增加了。在 chemoembolization 以后，在 VX-2 肿瘤圆周的区域的细胞的坏死在 chemoembolization 前比那更显著地高。在 VX-2 肿瘤的死了的房间的区域表明了低信号和高模数转换器价值，当可行房间的区域表明了高信号和低模数转换器价值时。结论：DWI 能检测并且区分肿瘤来自在 chemoembolization 前后的可行细胞的区域的坏死的区域。正常肝实质和 VX-2 肿瘤的模数转换器被细胞内部的浮肿影响，织物在 chemoembolization 以后的细胞的死亡

英文摘要：

AIM： To investigate dynamic characteristics and pathological mechanism of signal in rabbit VX-2 tumor model on diffusion-weighted imaging （DWI） after chemoembolization. METHODS： Forty New Zealand rabbits were included in the study and forty-seven rabbit VX-2 tumor models were raised by implanting directly and intrahepatically after abdominal cavity opened. Forty VX-2 tumor models from them were divided into four groups. DWI was performed periodically and respectively for each group after chemoembolization. All VX-2 tumor samples of each group were studied by pathology. The distinction of VX-2 tumors on DWI was assessed by their apparent diffusion coefficient （ADC） values. The statistical significance between different time groups, different area groups or different b-value groups was calculated by using SPSS12.0 software. RESULTS： Under b-value of 100 s/mm^2, ADC values were lowest at 16 h after chemoembolization in area of VX-2 tumor periphery, central, and normal liver parenchyma around tumor, but turned to increase with further elongation of chemoembolization treatment. The distinction of ADC between different time groups was significant respectively （F = 7.325, P 〈 0.001; F = 2.496, P 〈 0.048; F = 6.856, P 〈 0.001）. Cellular edemain the area of VX-2 tumor periphery or normal liver parenchyma around tumor, increased quickly in sixteen h after chemoembolization but, from the 16th h to the 48th h, cellular edema in the area of normal liver parenchyma around tumor decreased gradually and that in the area of VX-2 tumor periphery decreased lightly at, and then increased continually. After chemoembolization, Cellular necrosis in the area of VX-2 tumor periphery was more significantly high than that before chemoembolization. The areas of dead cells in VX-2 tumors manifested low signal and high ADC value, while the areas of viable cells manifested high signal and low ADC value. CONCLUSION： DWI is able to detect and differentiate tumor necrotic areas from viable cellular areas before and after