This paper deals with the existence and uniqueness of periodic solutions of the following scalar neutral Volterra integro-differential equation with infinite delaywhere a, C, D, f are continuous functions, also a(t + T) = a(t), C(t + T,s + T) = C(t, s), D(t + T,s + T) = D(t, s), f(t + T) = f(t). Sufficient conditions on the existence and uniqueness of periodic solution to this equation are obtained by the contraction mapping theorem.