中文摘要：

目的探讨miR-375在高血压颈动脉斑块阳性患者的表达变化情况及其临床意义。方法检测23例高血压颈动脉斑块阳性患者（实验组）的血压和血清miR-375表达水平,并与12例健康者（对照组）比较。结果实验组的收缩压、舒张压、颈动脉内中膜厚度（IMT）和miR-375表达平均水平分别为（170.4±6.0）mm Hg、（106.3±8.7）mm Hg、（1.28±0.08）mm和（3.53±0.77）,对照组分别为（132.2±3.8）mm Hg、（86.4±6.6）mm Hg、（0.83±0.17）mm和（2.36±0.76）,实验组的收缩压和舒张压平均水平明显高于对照组（P〈0.01）,miR-375表达的平均水平也明显高于对照组（P〈0.01）。结论 miR-375或许作为致病因素,而不是保护因素参与高血压颈动脉斑块阳性疾病的发生和发展,miR-375过高表达对高血压颈动脉斑块阳性患者疾病可能有促进作用。

英文摘要：

Objective To investigate expression changes of MiR-375 in hypertensive patients with carotid artery plaque positive and its clinical significance. Methods Blood pressure and expression levels of 23 patients with carotid artery plaque positive（ experimental group） were detected,and they were compared with those of 12 healthy people（ control group）. Results Systolic pressure,diastolic pressure,intima-media thicknesses（ IMT） and miR-375 average of the experimental group was（ 170. 4 ± 6. 0） mm Hg,（ 106. 3 ± 8. 7） mm Hg,（ 1. 28 ± 0. 08） mm and（ 3. 53 ± 0. 77） respectively,and those of the control group were（ 132. 2 ± 3. 8） mm Hg,（ 86. 4 ± 6. 6） mm Hg,（ 0. 83 ± 0. 17） mm and（ 2. 36 ± 0. 76） respectively. Average of systolic pressure and diastolic pressure in the experimental group were significantly higher than those of the control group（ P〈 0. 01）,and the average of miR-375 expression was also higher than that of the control group（ P〈 0. 01）. Conclusion miR-375 may be pathogenic factor,rather than protect factors involving in occurrence and development of hypertension carotid plaques positive disease. Excessive expression of miR-375 may promot carotid artery plaque positive disease in hypertension patients.