中文摘要：

目的探讨铁皮石斛处方辅助治疗血栓闭塞性脉管炎（TAO）患者的临床效果和白细胞介素-6（IL-6）、白细胞介素-8（IL-8）和肿瘤坏死因子-α（TNF-α）水平变化与效果。方法选取TAO患者62例,经医院伦理委员会审批,随机分为治疗组和对照组两组,每组31例,对照组单纯用西药药物治疗,治疗组用铁皮石斛处方加西药药物治疗;两组疗程均为3个月。比较两组患者治疗前后临床效果和血清IL-6、IL-8和TNF-α水平。结果治疗组临床有效率96.8%,对照组临床有效率93.5%,两组临床有效率差异没有统计学意义（χ2=0.553,P=0.758）;治疗组治疗前IL-6、IL-8和TNF-α水平分别为（4.25±2.71）ng/L、（826.0±97.3）ng/L和（4.62±2.32）ng/L,治疗后分别为（1.33±0.61）ng/L、（231.7±76.0）ng/L和（1.74±0.54）ng/L。对照组治疗前为（4.18±2.35）ng/L、（852.4±84.5）ng/L和（4.43±2.16）ng/L,治疗后为（3.57±2.16）ng/L、（619.8±73.4）ng/L和（3.97±1.61）ng/L。两组治疗前血清IL-6、IL-8和TNFα平均值高,治疗后两组患者IL-6、IL-8和TNF-α水平均有不同程度降低（P〈0.01）;治疗组治疗后血清IL-6、IL-8平均水平低于对照组（P〈0.01）,提示治疗组对患者免疫损伤的改善作用优于对照组。结论铁皮石斛处方辅助治疗TAO对改善患者的临床症状和炎症细胞因子功能紊乱的效果优于单纯用西药治疗,为提高临床疗效奠定基础。

英文摘要：

Objective To discuss iron caulis dendrobium prescription auxiliary treatment of thromboangiitis obliterans（TAO） in patients with clinical effect and interleukin 6（IL-6）, interleukin 8（IL-8） and tumor necrosis factor alpha-α（TNF-α） level change and the effect. Methods Approved by hospital ethics committee, 62 cases of patients with TAO were selected and randomly divided into treatment group and control group with 31 cases in each. Patients in control group were only treated with western medicine drugs, and patients in treatment group were treated with iron caulis dendrobium prescription plus western medicine drugs. The course of the two group was three months. the clinical effect and the level of serum IL-6, IL-8 and TNF-α of the two groups before and after the treatment were compared. Results Clinical effective rate of treatment group was 96.8%, and the clinical effective rate of control was 93.5%, and the difference was not statistically significant betweem the two groups（χ2 = 0.553, P=0.553）. The serum IL-6, IL-8 and TNF-α of treatment group before treatment were（4.25±2.71）ng/L,（826.0±97.3）ng/L and（4.62±2.3）ng/L, and the serum IL-6, IL-8 and TNFα of treatment group after treatment were（1.33±0.61）ng/L,（231.7±76.0）ng/L and（1.74±0.54）ng/L. The serum IL-6, IL-8 and TNF-α of control group before treatment were（4.18±2.35）ng/L,（852.4±84.5）ng/L and（4.43±2.16）ng/L, and the serum IL-6, IL-8 and TNF-α of control group after treatment were（3.57±2.16）ng/L,（619.8±73.4）ng/L and（3.97±1.61）ng/L. The average of serum IL-6, IL-8 and the level of TNF-α of the two groups were high before treatment, and after treatment, serum IL-6,IL-8 and the level of TNF-α of the two groups had varying degrees of reduction（P〈0.01）. The average levels of serum IL-6 and IL-8 in treatment group were lower than those in control group（P〈0.01）, which showed that the improvement of immune injury in treatment group was better than that in control group. C