中文摘要：

目的探讨急性胰腺炎（acutepancreatitis，AP）早期与胰岛素抵抗（IR）的关系，揭示AP胰岛素抵抗的机制。方法通过52例AP患者与30名健康成人在身高、体质量、血压、血脂、空腹血糖（FBG）、空腹胰岛素（FINS）水平等进行比较研究，阐明AP胰岛素抵抗的机制。结果重症胰腺炎（SAP）患者甘油三酯（TG）、FBG和FINS均值与对照组比较差异有统计学意义（P〈0．01），轻症胰腺炎（MAP）与SAP比较FINS差异有统计学意义（P〈0．01）。AP患者IR患病率、胰岛素抵抗指数和胰岛B细胞功能指数与对照组比较差异有统计学意义（P〈0．01）；MAP胰岛素抵抗观察指标与SAP比较差异也有统计学意义（P〈0．01）。结论MAP患者早期胰岛素抵抗局限于糖和胰岛素代谢紊乱为主，而SAP患者早期其糖、胰岛素和脂蛋白代谢均有紊乱现象，临床上应当关注AP的胰岛素抵抗情况，做到早期发现，早期干预。

英文摘要：

Objective To investigate the correlation between insulin resistance and early acute pancreatitis（ acute pancreatitis, AP）, and reveal the mechanism of insulin resistance in AP patients. Methods We enrolled 52 patients with acute pancreatitis and 30 healthy controls in this project, the aim of this study was to evaluate the height, weight, blood pressure, blood lipids, fasting blood glucose （FBG）, fasting insulin （FINS） level to clarify the mechanism of insulin resistance in AP patients. Results There were significant differences of the TG, FBG and FINS in severe acute pancreatitis （SAP） Patients （P 〈 0. 01 ）. Meanwhile there were significant differences of FINS between MAP and SAP （ P 〈 0. 01 ）. A difference statistically significant was found between prevalence and insulin resistance and β - cell function index in AP patients （ P 〈 0.01 ）. Likewise, there were significant differences in SAP and the outcome measure of the MAP （ P 〈 0.01 ）. Conclusion We should be concerned about the IR in AP patients to achieve early detection, early intervention in the clinical, in that the insulin and glucose metabolism disorder Play a leading role in insulin resistance of early AP, but Lipoprotein metabolism disorders phenomenon also play a role in SAP.