目的:探讨高效抗逆转录病毒治疗(HAART)艾滋病合并急性盆腔炎(AIDS+APID)患者临床疗效,为规范AIDS+APID治疗提供理论依据。方法:抽取25例排除其他感染的AIDS+APID患者,用HAART治疗3个月,于治疗前后观察患者症状、体征、宫颈管分泌物镜检、CD4^+T细胞计数和HIV裁量变化,观察患者是否出现ARV药物的严重不良反应:如骨髓抑制、胰腺炎、重症皮疹、高脂血症、严重的肝功能异常等。结果:治疗后患者腹胀、下腹部压痛、肌紧张,性交疼痛等症状消退;异常的阴道分泌物消退;子宫附件区压痛、宫颈举痛或摇摆痛体征消退;输卵管壁增厚、管腔积液、盆腔积液或输卵管卵巢脓肿等消退;阴道杆菌、球菌、上皮细胞和脓(白)细胞等阴道清洁度观察指标明显好转(P〈0.01);CD4^+T细胞计数由低转高(χ^2=43.600,P〈0.01),HIV裁量由高转低(χ^2=40.400,P〈0.01),没有出现ARV药物的严重不良反应。结论:对于AIDS+APID患者,临床上如果能完全排除合并其他感染,用HAART治疗可以消除APID的临床症状和体征,没有出现ARV药物的严重不良反应,因观察例数比较少,仍需重复验证。
OBJECTIVE To investigate clinical efficacy of highly active antiretroviral therapy(HAART)against HIV/AIDS complicated with acute pelvic inflammatory disease(AIDS+APID),provide a theoretical basis for standardizing AIDS+APID therapy.METHODS Twenty five patients only with AIDS+APID were randomly selected,HAART therapy was administered for 3 months.The patients were observed for symptoms,signs,cervix secretion microscopy,changes of CD4^+T cell count and HIV discretion before and after treatment.RESULTS After treatment,abdominal distention,abdominal tenderness,muscle tension,sexual intercourse pain and other symptoms subsided;abnormal vaginal discharge subsided;uterine accessories tenderness,cervical pain or swing pain subsided;fallopian tube wall thickening,tube cavity effusion,pelvic cavity fluid or oviduct ovarian abscess faded;vaginal coli,staphylococcus aureus,epithelial cells and pus(white),such as vaginal cleanness observation index alleviated significantly(P〈0.01);CD4^+T cell count changed from low to high levels(χ^2=43.600,P〈0.01),HIV load from high to low levels(χ^2=40.400,P〈0.01).CONCLUSION For AIDS+APID patients with other infection completely excluded,HAART can eliminate APID clinical signs and symptoms.