中文摘要：

目的 探讨小分子化合物J2在抑制小鼠皮肤移植排斥反应的作用。方法 以C57BL／6小鼠为供体，以BALB／c小鼠为受体建立皮肤移植实验模型，随机分为A、B、C组，并分别以CsA、J2、空白液连续ig 12d为干预手段，比较各组移植皮瓣的存活时间和存活率，术后14d对各组做组织学检查。结果J2组发生排斥时间延迟，同种异体移植对照组皮瓣平均存活时间为（13．7±1．4）d，J2组为（17．7±2．4）d，两组差异有统计学意义，CsA组存活时间为（18．2±2．1）d，与J2组比较存活时间、存活率差异均无统计学意义。组织学检查证实，术后14d J2组植片未见明显的淋巴细胞浸润。结论 J2有抑制小鼠皮肤移植排斥作用。

英文摘要：

Aim To investigate the effects of J2 on prevention of skin allograft rejection in mouse skin transplantation.Methods The C57BL/6 and BALB/c were used as donors and recipients to establish a skin allograft model, and dividedinto 3 groups randomly. Group A, allograft control （this group was given placebo only） ; group B and group C, allograftgroups,were treated with orally CsA and J2,respectively.The drugs were delivered for 12 days from the day of transplantation. Graft survival was assessed by Kaplan-Meier analysis. Fourteen days after transplantation, histological examinationwas performed to confirm the clinical diagnosis of rejection. Results The average transplant survival time in the allograftcontrol （Group A） was （13.7±1.4）d. Treatment with J2 （Group C） led to a statistically significant prolongation oftransplant survival to （17.7±2.4）d （ P〈0.01）,but compared with treatment with CsA （Group B） （18.2±2.1）d,there was no statistically significant difference between the two groups（ P 〉 0.05）. Fewer inflammatory cells were foundin the skin allograft of J2 group. Conclusion These results showed that J2 could prevent skin graft rejection.