过氧化物氧还蛋白(peroxiredoxin,Prx)家族是细胞中一类高丰度蛋白质,作为过氧化物酶对维持体内过氧化氢水平发挥着重要的作用,并且通过调控蛋白激酶的氧化还原状态参与细胞信号转导调控过程。Prx家族根据其参与催化反应的半胱氨酸残基数目分为典型双半胱氨酸型(2-Cys)、非典型双半胱氨酸型(atypical 2-Cys)和单半胱氨酸型(1-Cys)。Prx的活性受到寡聚化状态、磷酸化以及蛋白质水解的调控。
Peroxiredoxin (Prx) protein family are a high-abundance protein enzymes that contribute to in vivo H2O2 level control and mediate cell signal transduction through regulating the redox state of protein kinases.Based on the cysteine residues conserved in the deduced amino acid sequence and their catalytic mechanisms,three subtypes of Prx have been distinguished,namely,2-Cys Prx,atycpical 2-Cys Prx,and 1-Cys Prx.The activity of Prx was regulated by polymerization,phosphorylation and proteolysis.