中文摘要：

目的观察创伤后应激障碍（PTSD）大鼠动眼神经核神经元5-羟色胺1A（5-HT1A）受体表达的变化。方法采用无连续单一刺激（SPS）方法，建立PTSD样大鼠SPS模型，随机分为SPS后1d、4d和7d组及正常对照组。应用免疫组化、Westernblot和透射电镜技术，检测动眼神经核神经元5-HT1A受体表达的变化，观察神经元超微结构的改变。结果SPS后大鼠动眼神经核神经元5-HT1A受体的表达高于正常对照组，尤以SPS后7d组最为明显；神经元超微结构也发生改变。结论SPS刺激可促进大鼠动眼神经核神经元5-HT1A受体的表达增强，进而导致神经递质紊乱，影响动眼神经核支配眼球肌的运动功能。出现相应的PTSD症状。

英文摘要：

Objective To observe the change of 5-HT1A receptor-expression in the oculomotor nucleus of posttraumatic stress disorder rats. Methods The SPS-method was used to set up the rat FTSD models. Rats were randomly divided into 1 d,4 d and 7 d groups of single prolong stress （SPS） and a normal group. Immunohistochemical and Western blot were used to detect the expression of 5-HT1A receptor in the oculomotor nucleus. The change of ultrastructure in the neuron were objected by transmission electron microscopy （TEM）. Results The expression of 5-HT1A receptor in the eculomotor nucleus neurons gradually increased on 1 d,4 d and 7 d after exposure to SPS than that of the control group,and reached the peak level at 7 d after SPS exposure. There was also a change of ultrastructure in the oculomotor nucleus neuron detected. Conclusion SPS exposure resulted in the change of 5-HT1A receptor expression in the oculomotor nucleus,which might be related to the pathogenesis of PTSD.