中文摘要：

为评价改性壳聚糖（CS）和CS复合物的抑菌效果,利用过氧化氢氧化法制备不同分子量的CS,通过官能团偶联的方法将甲基聚乙二醇单甲醚（mPEG）接枝到CS分子上制备水溶性的CS衍生物（mPEG-g-CS）;戊二醛（gluteradehyde,GA）交联法制备了β-环糊精（β-CD）-CS复合物。傅利叶红外光谱分析证明CS骨架上的-NH2由于发生了衍生化反应而使得氢键消失,CS与mPEG发生了接枝反应。金黄色葡萄球菌（S.aureus）和大肠杆菌（E.coli）进行抑菌实验结果表明：分子量为十万左右,浓度为20 mg.L-1的CS（CS1）对两种菌抑菌效果明显,改性后的CS对S.aureus,E.coli抑菌效果均降低。

英文摘要：

The objective is to evaluate the antibacterial capability of modified chitosan and chitosan compounds.Chitosan with different molecular weight was prepared by oxidizing chitosan with H2O2.The water-soluble chitosan derivatives were synthesized through grafting with mPEG.β-cyclodextrin-chitosan compounds were prepared using gluteradehyde as crosslinker.FT-IR analysis indicated that the amino groups on the chitosan backbone occurred derivative reactions which caused disappearance of hydrogen bonds,grafting reactions were also occurred between CS and mPEG.Antibacterial tests using Escherichia coli and Staphylococcus aureus as test strains showed that chitosan with molecular weight at 100 000 and concentration at 20 mg·L-1（named as CS1） has significant inhibitive effects on bacterial growth.However,the modified chitosan lost most of its antibacterial ability.