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中药苦参主要黄酮类成分的研究
  • 期刊名称：中药苦参主要黄酮类成分的研究，李巍，梁鸿，尹婷，王邠，赵玉英，药学学报, 2008, 43(8) :
  • 时间：0
  • 分类：R284.1[医药卫生—中药学;医药卫生—中医学] R284.2[医药卫生—中药学;医药卫生—中医学]
  • 作者机构：[1]北京大学药学院天然药物学系和天然药物及仿生药物国家重点实验室,北京100083
  • 相关基金：国家自然科学基金重点资助项目（20432030）;长江学者和创新团队计划资助项目（985-2-063-112）.
  • 相关项目：高效快速新颖结构天然产物的发现及其生物活性研究
关键词： 苦参, 二氢黄酮, 2′-羟基异黄腐醇, 5-甲氧基-7, 2′, 4′-三羟基-8-异戊烯基二氢黄酮, Sophora flavecens Ait. , flavanones , 2′-hydroxyisoxanthohumol , 5-methoxy-7,2′, 4′- trihydroxy-8-[ 3,3-dimethyl allyl ] -flavanone
中文摘要：

中药苦参为豆科槐属植物苦参Sophora flavescenes Ait．的干燥根，具有清热燥湿、杀虫利尿的功能，主治热痢便血、阴肿阴痒、湿疹、皮肤搔痒，外用治疗滴虫性阴道炎等。黄酮是苦参中一类重要的活性成分，为建立苦参黄酮质量控制方法提供对照品，研究苦参黄酮抗滴虫和抗菌等作用机制和构效关系，首先对其主要黄酮类成分进行了研究，从中分离鉴定了6个主要化合物，分别为5-甲氧基-7，2′，4′-三羟基-8-异戊烯基二氢黄酮（1）、异黄腐醇（2）、3β，7，4′-三羟基-5-甲氧基-8-异戊烯基二氧黄酮（3）、降苦参酮（4）、苦参酮（5）和苦参醇Ⅰ（6）。化合物1为新化合物，化合物3为首次从本棺物得到．并首次报道了化合物3和5的^13C NMR数据．

英文摘要：

Radix Sophorae Flavescentis is a traditional Chinese medicine, which is the roots of Sophora flavescens and is used to treat abscess, dysentery, eczema and skin itch. The main active compounds of the roots of Sophora flavescens are alkaloids and flavonoids. To provide reference compounds for HPLC-DAD qualitification analysis of flavanonoids and for study on the bioactivities of flavanonoids, six main flavanonoids were isolated from the roots of Sophora flavescens. They are 5-methoxy-7, 2′, 4′- trihydroxy-8- [ 3,3-dimethylallyl ] -flavanone （ 1 ）, isoxanthohumol （ 2 ）, 3β,7,4′-trihydroxy-5-methoxy-8- [ 3,3-dimethylallyl ] -flavanone （3）, nor-kurarinone [ （2S） -sophoraflavanone G ] （4）, kurarinone （S） and kushenol Ⅰ （6）. Compound 1 is a new compound, and compound 3 is obtained from Sophoraflavecens for the first time. The ^13C NMR data of compounds 3 and 5 are reported for the first time.

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高效快速新颖结构天然产物的发现及其生物活性研究
期刊论文 162 著作 3
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