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Application of Xenopus laevis in ecotoxicology (Ⅰ)—Introduction and quality control of laboratory animal
  • ISSN号:1001-604X
  • 期刊名称:《中国化学:英文版》
  • 时间:0
  • 分类:R994[医药卫生—毒理学;医药卫生—药学]
  • 作者机构:[1]State Key Laboratory of Environmental Chemistry and Ecotoxicology,Research Center for Eco-environmental Sciences, Chinese Academy ofSciences, Beijing 100085, China
  • 相关基金:This work was supported by the National Natural Science Foundation of China (Grant Nos.20377044 and 20437020),the National High Technology Research and Development Program of China (Grant No.2003AA646010).and the National Basic Research Program of China (Grant No.2003CB415005).
中文摘要:

报纸的系列的目的是讨论 Xenopuslaevis 的申请,作为在生物学的模型动物,在 ecotoxicology。X。laevis 疯狂在生物学习被用作模型动物并且因为许多优点,提供了很多联系数据,生整个年里的鸡蛋,例如住在水并且容易被维持,并且外部地使肥沃并且发展中。X 的胚胎和幼虫。象另外的两栖动物一样的 laevis 直接在水的环境被暴露并且对污染物质敏感。另外, X 的性区别和性器官开发。laevis 对性荷尔蒙敏感并且内分泌与性荷尔蒙活动破坏 ers,它启用 X。在性荷尔蒙混乱和繁殖毒性上在研究要过去常的 laevis 内分泌破坏 ors。X 的变形开发。laevis 对甲状腺激素和甲状腺很敏感破坏 ors,它启用 X。laevis 将被用于评估 thyroiddisruptors。另外, X。laevis ecotoxicology 能与两栖动物人口衰落和畸形的青蛙出现被连接,是在生态学的热点之一。因此,越来越多的实验室介绍了 X。laevis 到 ecotoxicological 学习。实验室动物的质量从动物实验与结果的 scientificity 和可靠性相关。它为毒物学是特别重要的。X 的质量控制。包含象水和食物那样的几个因素的 laevis 在这篇论文被讨论。

英文摘要:

The aim of the series of papers is to discuss the application of Xenopus laevis, as model animal in biology, in ecotoxicology. X. laevis as model animal is wildly used in biological study and has provided a lot of relating data because of many advantages, such as living in water and being easily maintained, laying eggs in the whole year, and externally fertilizing and developing. Embryos and larvae of X. laevis like other amphibians are directly exposed in the aquatic environment and sensitive to pollutants. In addition, sex differentiation and sex organ development of X. laevis are sensitive to sex hormones and endocrine disruptors with sex hormone activities, which enable X. laevis to be used in studies on sex hormone disruption and reproductive toxicity of endocrine disruptors. Metamorphic development of X. laevis is very sensitive to thyroid hormones and thyroid disruptors, which enables X. laevis to be used for evaluating thyroid disruptors. Also, X. laevis ecotoxicology can be linked with amphibian population declines and malformed frog occurrence, being one of the hotspots in ecology. Thus, more and more laboratories have introduced X. laevis to ecotoxicological study. The quality of laboratory animals correlates with scientificity and reliability of results from animal experiments. It is especially important for toxicology. Quality control of X. laevis involving several factors such as water and food is discussed in this paper.

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期刊信息
  • 《中国化学:英文版》
  • 主管单位:
  • 主办单位:中国化学会
  • 主编:
  • 地址:上海市枫林路354号中科院上海有机化学研究所
  • 邮编:200032
  • 邮箱:
  • 电话:021-54925243
  • 国际标准刊号:ISSN:1001-604X
  • 国内统一刊号:ISSN:31-1547/O6
  • 邮发代号:4-646
  • 获奖情况:
  • 中国期刊方阵“双高”期刊
  • 国内外数据库收录:
  • 美国化学文摘(网络版),荷兰文摘与引文数据库,美国科学引文索引(扩展库),日本日本科学技术振兴机构数据库,英国英国皇家化学学会文摘
  • 被引量:175