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中文摘要：
在线样品前处理液相色谱-质谱联用技术为体液中痕量小分子化合物提供了高灵敏度、高选择性和高通量的分析方法。该文以在线固相萃取柱为主线,总结了不同种类富集柱的特点及其近5年来在相关领域的应用,并简要介绍了在线液相色谱-质谱分析的流路系统
英文摘要：
On-line liquid chromatography-mass spectrometry （LC-MS） is a highly sensitive, highly selective and high throughput method for the analysis of small molecules in biofluids. The developments, characterizations and applications of pre-column, on-line LC-MS method and its configuration in the recent five years are reviewed.
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Rapid and sensitive determination of polycyclic aromatic hydrocarbons in atmospheric particulates us
Separation of the positional isomers of phthalic acids in hydro-organic solvents using capillary ele
Automated on-line liquid chromatography-photodiode array-mass spectrometry method with dilution line
Flow injection analysis of total inorganic carbon and total organic carbon in waters by H2O2–luminol
Molecularly imprinted solid phase extraction and flow injection chemiluminescence for trace analysis
On-line liquid chromatography-mass spectrometry with dilution line to achieve large volume urine inj
Development of an on-line sample pretreatment liquid chromatography-mass spectrometry system for the
Preparation, Characterization and Application of L-Cysteine Functionalized Multi-walled Carbon Nanot
Phthalate esters in sediments from Guanting reservoir and the Yongding River, Beijing, People’s Repu
Polychlorinated Biphenyls in fish species from Guanting reservoir, Beijing, People’s Republic of Chi
Xenopus laevis is a potential alternative model animal species to study reproductive toxicity of phy
Application of surfactants and microemulsions to the extraction of pyrene and phenanthrene from soil
Evaluation of Expanded Graphite as On-Line Solid-Phase Extraction Sorbent for High Performance Liqui
Interfacing Capillary Electrophoresis and Electrothermal Atomic Absorption Spectrometry to Study Met
Speciation analysis of inorganic arsenic by microchip capillary electrophoresis coupled with hydride
Development of a Fiber-in-Tube Microextraction Protocol for Gas Chromatography-Electron Capture Dete
Experimental studies on the chemiluminescence reaction mechanism of carbonate/bicarbonate and hydrog
Study of low molecular weight organic acids in maize roots under the stress of cadmium using capilla
Study on the generation mechanism of reactive oxygen species on calcium peroxide by chemiluminescenc
Chemiluminescence of ClO3- - SO32- - Rh6G-SDBS system and its application for the determination of s
Determination of particle-associated polycyclic aromatic hydrocarbons (PAHs) in urban air of Beijing
Polybrominated diphenyl ethers in leaves and soil from typical electronic waste polluted area in Sou
Polybrominated Diphenyl Ethers in Mudsnails (Cipangopaludina cahayensis) and Sediments from an Elect
Application of Xenopus laevis in ecotoxicology（I）——Introduction and quality control of laboratory an
On-line preparation of peroxymonocarbonate and its application for the study of energy transfer chem
Study on superoxide and hydroxyl radicals generated in indirect electrochemical oxidation by chemilu
Solid-phase extraction with C30-bonded silica for analysis of polycyclic aromatic hydrocarbons in ai
Determination of substituted benzenes in water samples by fiber-in-tube liquid phase microextraction
Preparation and evaluation of a molecularly imprinted sol-gel material for on-line solid-phase extra
Sensitive measurement of ultratrace phenols in natural water by purge-and-trap with in situ acetylat
CE with On-line Detection by ICP-MS for Studying the Competitive Binding of Zinc against Cadmium for
A polymeric master replication technology for mass fabrication of poly(dimethylsiloxane) microfluidi
Comparison of traditional cloud-point extraction and on-line flow-injection, with a chemiluminescenc
Development of a sensitive micro-magnetic chemiluminescence enzyme immunoassay for the determination
Determination of triazines herbicides in fruits and vegetables using dispersive solid-phase extracti
Short-column capillary electrophoresis coupled with inductively coupled plasma mass spectrometry for
A Room Temperature Ionic Liquid Mediated Non-hydrolytic Sol-Gel Methodology to Prepare Molecularly I
Probing mercury species-DNA interactions by electrophoresis with on-line electrothermal atomic absor
On-line hyphenation of flow injection, miniaturized capillary electrophoresis and atomic fluorescenc
Exploration of coordination polymer as sorbent for flow injection on-line solid phase extraction cou
Chemiluminescence Energy Transfer Reaction for the on-line preparation of peroxymonocarbonate and Eu
A selective optical chemical sensor for 2,6-dinitrophenol based on fluorescence quenchment of a nove
Review: Distribution and characterization of polycyclic aromatic hydrocarbon compounds in airborne p
Separation and determination of norepinephrine, epinephrine and isoprinaline enantiomers by capillar
Levels and distribution of polybrominated diphenyl ethers in various tissues of foraged hens from el
Chiral separation of FITC-labeled amino acids with gel electrochromatography using a polydimethylsil
On-line enrichment and determination of polycyclic aromatic hydrocarbons in atmospheric particulates
Sensitive monitoring of humic acid in various aquatic environments with acidic cerium chemiluminesce
Temperature effects on the enantioselectivity of basic analytes in CZE using highly sulfated β-cyclo
A wintertime of polycyclic aromatic, hydrocarbons in PM2.5 and PM2.5-10 in Beijing: assessment of en
In vitro monitoring of nanogram levels of naproxen in human urine using flow injection chemiluminesc
Determination of phenol in landfill leachate by using microchip capillary electrophoresis with end-c
Simultaneous determination of Cr(III) and Cr(VI) with prechelation of Cr(III) using phthalate by ion
Continuous-flow microextraction and gas chromatographic-mass spectrometric determination of polycycl
Determination of chromium(III) and total chromium using dual channels on glass chip with chemilumine
Determination of riboflavin by enhancing the chemiluminescence intensity of peroxomonosulfate-cobalt
Enhancement in sample preconcentration by the on-line incorporation of cloud point extraction to flo
Flocculation-ultrasonic assisted extraction and solid phase clean-up for determination of polycyclic
Study of the enantioseparation of imazaquin and enantioselective degradation in field soils by capil
Comparison of two capillary electrophoresis on-line stacking modes by analysis of polycyclic aromati
Cigarette filter as sorbent for on-line coupling of solid-phase extraction to high-performance liqui
Extracting the Binding Stoichiometry, Thermodynamics and Kinetics for the Interaction of DNA with Ca
Selective detection of trace lead in lead-free solder alloy by flow injection on-line solid-phase ex
Multiwalled carbon nanotubes coated fibers for solid-phase microextraction of polybrominated dipheny
Ultrasensitive determination of cadmium in seawater by hollow fiber supported liquid membrane extrac
Accumulation features of organochlorine pesticides and heavy metals in fish from high mountain lakes
Investigation of organochlorine pesticides (OCPs) in mollusks collected from coastal sites along the
Facile synthesis of cleistetroside-2, a partially acetylated oligorhamnoside from Cleistopholis glau
Vitellogenic responses of 17β-estradiol and bisphenol A in male Chinese loach (Misgurnus anguillicau
Rapid and complete destruction of perchlorate in water and ion-exchange brine using stabilized zero-
Online concentration of aristolochic acid I and II in Chinese medicine preparations by micellar elec
Evaluation of carbon nanotubes as a solid-phase extraction adsorbent for the extraction of cephalosp
Polychlorinated dibenzo-p-dioxins and dibenzofurans in eggs of eight avian species from Dongting Lak
Profiles of polychlorinated dibenzo-p-dioxins and dibenzofurans in fish livers and gills from Dongti
Preparation of a biochip on porous silicon and application for label-free detection of small molecul
Determination of triadimenol based on the quenching effect on resonance light scattering from the tr
Determinations of dioxinlike activity in selected mollusks from the coast of the Bohai Sea, China, u
Binding interaction between polycyclic aromatic compounds and DNA by fluorescence displacement metho
Remediation of organic and inorganic arsenic contaminated groundwater using a nanocrystalline TiO2-b
Perspectives on the inclusion of perfluorooctane sulfonate into the Stockholm convention on persiste
Immobilization of non-point phosphorus using stabilized magnetite nanoparticles with enhanced transp
Identification of reactive cysteines in a protein using arsenic labeling and collision-induced disso
Acute enhancement of synaptic transmission and chronic inhibition of synaptogenesis induced by perfl
Photoelectrochemical sensor for the rapid detection of in Situ DNA damage induced by enzyme-catalyze
Distribution and temporal trends of butyltins monitored by molluscs along the Chinese Bohai coast fr
Perfluorinated compounds and total and extractable organic fluorine in human blood samples from Chin
Preliminary hazard assessment of polychlorinated biphenyls, polybrominated diphenyl ethers, and poly
Impacts of some environmentally relevant parameters on the sorption of polycyclic aromatic hydrocarb
Simple interface of high-performance liquid chromatography-atomic fluorescence spectrometry hyphenat
Distribution of organochlorine pesticides (OCPs) in conifer needles in the southeast Tibetan Plateau
In situ fabrication of nanostructured titania coating on the surface of titanium wire: A new approac
Simultaneous speciation of monomethylmercury and monoethylmercury by aqueous phenylation and purge-a
Stacking and separation of urinary porphyrins in capillary electrophoresis: Optimization of concentr
Mixed hemimicelles solid-phase extraction based on cetyltrimethylammonium bromide-coated nano-magnet
Study on the Retention Behavior of Aromatic Carboxylic and Sulfonic acid on a New Anion Exchange Col
Determination of triazine herbicides in fruits and vegetables using dispersive solid-phase extractio
Characterization of the DNA Adducts Induced by Aristolochic Acids in Oligonucleotides by Electrospra
Molecularly imprinted solid-phase extraction and flow-injection chemiluminescence for trace analysis
A two-hybrid yeast assay to quantify the effects of xenobiotics on thyroid hormone-mediated gene exp
Prediction of the environmental fate and aquatic ecological impact of nitrobenzene in the Songhua Ri
Pesticide contamination profiles of water, sediment and aquatic organisms in the effluent of Gaobeid
Effects of 2,4-dichlorophenol on the expression of vitellogenin and estrogen receptor genes and phys
Levels and geographic Distribution of 2,4-dichlorophenol, 2,4,6-trichlorophenol, pentachlorophenol i
Tissue-dependent distribution and bioaccumulation of polychlorinated dibenzo-p-dioxins and dibenzofu
The acute lethality and endocrine effect of 1,2,3,7,8-PeCDD in juvenile goldfish (Carassius auratus)
Biomimetic accumulation of PAHs from soils by triolein embedded cellulose acetate membranes (TE CAMs
Study of the Study of Protein Binding and Micellar Partition of Highly Hydrophobic Molecules in a Si
Investigation of levels and fate of triclosan in environmental waters from the analysis of gas chrom
Influences of 4-nonylohenol on dmrt1 gene expression and vitellogenin mRNA induction of adult rare m
Assessment of 17α-ethinylestradiol effects and underlying mechanisms in a continuous, multi-generati
A two-hybrid yeast assay to quantify the effects of xenobiotics on retinoid X receptor-mediated gene
Levels and distributions of polychlorinated naphthalenes in sewage sludge of urban wastewater treatm
Photoelectrochemical detection of oxidative DNA damage induced by fenton reaction with low concentra
Part-per-trillion level detection of estradiol by competitive fluorescence immunoassay using DNA/dye
E-waste recycling induced polybrominated diphenyl ethers, polychlorinated biphenyls, polychlorinated
Rapid screening method for intact glucosinolates in Chinese medicinal herbs by using liquid chromato
Quantification of aristolochic acid-derived DNA adducts in rat kidney and liver by using liquid chro
Cloud point extraction as an advantageous preconcentration approach for analysis of trace silver nan
Development of redox-labeled electrochemical immunoassay for polycyclic aromatic hydrocarbons with c
Combined fluorescence and electrochemical investigation on the binding interaction between organic a
Highly sensitive detection of human thrombin in serum by affinity capillary electrophoresis/laser-in
Ultra-performance liquid chromatography-tandem mass spectrometry for rapid and highly sensitive anal
Triton X-114 based cloud point extraction: a thermoreversible approach for separation/ concentration
Predicting bioavailability of PAHs in field-contaminated soils by passive sampling with triolein emb
Synthesis and Characterization of DNA Fluorescent Probes Containing a Single Site-Specific Stereoiso
Influence of Glomus etunicatum/Zea mays mycorrhiza on atrazine degradation, soil phosphatase and deh
Development of negligible depletion hollow fiber membrane-protected liquid-phase microextraction for
Mutations in influenza virus replication and transcription: Detection of amino acid substitutions in
Interactions between estrogenic chemicals in binary mixtures investigated using vitellogenin inducti
Uptake and acropetal translocation of polycyclic aromatic hydrocarbons by wheat (Triticum aestivum L
Helical- and ahelical-dependent chiral recognition mechanisms in capillary electrophoresis using amy
Levels and Vertical Distributions of PCBs, PBDEs, and OCPs in the Atmospheric Boundary Layer: Observ
Changes in synaptic transmission, calcium current, and neurite growth by perfluorinated compounds ar
Identification and evaluation of a novel heterocyclic brominated flame retardant tris(2,3-dibromopro
Identification of Amino Acid Substitutions in Avian Influenza Virus (H5N1) Matrix Protein by Using N
Combination of β-elimination and liquid chromatography/quadrupole time-of-flight mass spectrometry f
Identification of Amino Acid Substitutions in Mutated Peptides of Nucleoprotein from Avian Influenza
On-line Capillary Electrophoresis-Electrospray Ionization Mass Spectrometry Analysis of Urinary Porp
Solid-phase extraction of sulfonylurea herbicides from water samples with single-walled carbon nanot
Analysis of Adenosine Phosphates in HepG-2 Cell by a HPLC-ESI-MS System with Porous Graphitic Carbon
A structure-based investigation on the binding interaction of hydroxylated polycyclic aromatic hydro
Assessing accumulation and biological effect of hydrophobic organic contaminants in water using cage
Superparamagnetic Fe3O4 nanoparticles as catalysts for the catalytic oxidation of phenolic and anili
Effect of cationic and anionic surfactants on the sorption and desorption of perfluorooctane sulfona
Molecularly imprinted solid-phase extraction for the selective determination of 17-estradiol in fish
Determination of brominated flame retardants in electrical and electronic equipments with microwave-
Comparison and optimization of several pretreatment techniques for determination of decabrominated d
Simultaneous determination of ten estrogens and their me tabolites in waters using improved two-step
The avoidance responses of Daphnia magna to the exposure of organophosphorus pesticides in an on-lin
Estimation and characterization of PCDD/Fs and dioxin-like PCB emission from secondary zinc and lead
A preliminary investigation on emission of polychlorinated dibenzo-p-dioxins/dibenzofurans and dioxi
Fluorescence polarization combined capillary electrophoresis immunoassay for the sensitive detection
Improved preparation and identification of aristolochic acid-DNA adducts by solid-phase extraction w
Evaluation of extraction methods for arsenic speciation in polluted soil and rotten ore by HPLC-HG-A
Application of self-assembled system based on ronic Surfactants adsorbed onto oxide surface in chemi
Structure-dependent response of a chemiluminescence nitrogen detector for organic compounds with adj
Interaction of methylmercury and selenium on the bioaccumulation and histopathology in medaka (Oryzi
Determination of atrazine, desethyl atrazine and desisopropyl atrazine in environmental water sample
Mechanism of metal-independent decomposition of organic hydroperoxides and formation of alkoxyl radi
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