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Selective α-Bromination of β-Keto Esters in Reusable PEG-400 under Mild and Catalyst-free Conditions
  • ISSN号：1001-604X
  • 期刊名称：《中国化学：英文版》
  • 时间：0
  • 分类：O623.733[理学—有机化学;理学—化学]
  • 作者机构：[1]Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research of Ministry of Education, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, Hunan 410081, China
  • 相关基金：Project supported by the Key Project of Chinese Ministry of Education （No. 206102）, Fok Ying Dong Education Foundation （No. 101012）, Scientific Research Fund of Hunan Provincial Education Department （No. 05B038）, Hunan Provincial Natural Science Foundation of China （No. 05JJ1002） and the National Natural Science Foundation of China （Nos. 20572020, 20202002）.
作者： 谢叶香[1], 唐石[1], 朱其明[1], 尹笃林[1], 李金恒[1]
关键词： 溴化作用, Β-酮酸酯, α-溴-β-酮酸酯, N-溴琥珀酰亚胺, PEG-400, bromination, β-keto ester, α-bromo-β-keto ester, N-bromosuccinimide, PEG-400
中文摘要：

为 -bromo--keto 酉旨的合成的一个有效 bromination 协议被开发了。在 PEG-400 (poly (乙烯 glycol-400 )) ，许多 -keto 酉旨在房间温度与 NBS (N-bromosuccinimide ) 被对待有选择地在优秀收益负担得起相应 -monobromination 产品。反应在温和、环境地良性、没有催化剂的条件下面被进行，是引人注目的。

英文摘要：

An efficient bromination protocol for the synthesis of α-bromo-β-keto esters has been developed. In PEG-400 （poly（ethylene glycol-400））, a variety of β-keto esters were treated with NBS （N-bromosuccinimide） at room temperature to selectively afford the corresponding α-monobromination products in excellent yields. It is noteworthy that the reaction was conducted under mild, environmentally benign and catalyst-free conditions.

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期刊信息
  • 《中国化学：英文版》
  • 主管单位:
  • 主办单位:中国化学会
  • 主编：
  • 地址：上海市枫林路354号中科院上海有机化学研究所
  • 邮编：200032
  • 邮箱：
  • 电话：021-54925243
  • 国际标准刊号：ISSN：1001-604X
  • 国内统一刊号：ISSN：31-1547/O6
  • 邮发代号:4-646
  • 获奖情况:
  • 中国期刊方阵“双高”期刊
  • 国内外数据库收录:
  • 美国化学文摘（网络版）,荷兰文摘与引文数据库,美国科学引文索引（扩展库）,日本日本科学技术振兴机构数据库,英国英国皇家化学学会文摘
  • 被引量:175