中文摘要：

目的 探讨肝乐灵对四氯化碳（CCl4）所致肝纤维化大鼠的保护作用。方法 50只雄性Wister大鼠采用CCl4复制肝纤维化模型后均分为五组：模型对照组,肝乐灵0.12、0.06、0.03g/kg高、中、低剂量组,秋水仙碱组。另取10只大鼠作为正常对照组。给药6周后检测大鼠血清中的ALT、AST、超氧化物歧化酶（SOD）、丙二醛（MDA）和羟辅氨酸（Hyp）,观察大鼠肝组织常规病理改变。结果 与正常对照组比较,模型对照组造模6周时ALT、AST、MDA、Hyp升高,SOD降低（P〈0.01）,常规病理提示肝细胞变性、坏死严重。肝乐灵剂量依赖性地降低CCl4致大鼠肝损伤血清ALT、AST、MDA、Hyp的升高,升高血清中SOD的活性（P〈0.05）。常规病理提示,肝乐灵中、高剂量组可明显减轻CCl4所致的大鼠肝细胞变性、坏死及肝组织损害程度。结论 肝乐灵对大鼠肝纤维化有一定的防治作用;其机制可能与抗脂质过氧化损伤有关。

英文摘要：

Objective To study the effects of Ganleling（a compound of Chinese medicine） on liver fibrosis induced by carbon tetrachloride in rats. Methods After established male Wister rat model with liver fibrosis, 50 rats were equally assigned into 5 groups of A （model control）, B （Ganleling 0. 12 g/kg gastric gavage daily for 6 weeks） ,C（Ganleling 0. 06 g/kg） D（Canleling 0. 03 g/kg） and F（colchicine gastric gavage）. Another 10 male Wister rats were taken as the normal controls （group F）. Serum ALl＇, AST, superoxide dismutase（SOD）, MDA and hydroxy tryptophan（Hyp） were detected at the end of treatment. The liver tissues were taken for the observation of pathology. Results Serum levels of ALT, AST, MDA and Hyp were higher, but SOD was lower, in group A than those in group F（P〈0. 01）, which in groups of B, D and E were significantly improved compared to group A（P〈0. 05）. Pathological examination showed obvious liver cell denaturation and necrosis in group A,which were slighter in groups of B,D and E. Conclusion Ganleling has a certain therapeutic effect on liver fibrosis in rats, which is possibly related to the alleviation of liver injury induced by lipid peroxidation.