欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
目的探讨miRNAs在紫杉醇耐药的乳腺浸润性微乳头状癌中的影响。方法收集2011年1月至2014年12月年天津市肿瘤医院11例乳腺浸润性微乳头状癌（invasive micropapillary carcinoma,IMPC）患者的组织切片,实时荧光定量PCR法检测其中miRNAs的表达。采用Target Scan和mi RDB预测miRNAs下游靶基因。结果根据前期研究结果筛选出13个耐药相关的miRNAs,其中与紫杉醇敏感的IMPC相比,miR-744-5p在紫杉类耐药IMPC中的表达水平升高了（t=-2.650,P=0.029）,差异有统计学意义。通过生物信息学分析预测发现,miR-744-5p可能通过调节CPFS4,Upf1和PP2A等靶基因影响紫杉醇耐药。结论 miR-744-5p可能参与调节IMPC的紫杉醇耐药,并可能成为其分子标记物。
英文摘要：
Objective To investigate the effect of miRNAs on chemosensitivity of invasive papillary carcinoma（ IMPC）.Methods 11 IMPC examples were got from Tianjin Cancer Hospital from 2011 to 2014.The expressions of miRNAs were tested by real time fluorescence quantitative PCR（ RT-q PCR） and target genes were predicted with Target Scan and mi RDB databases.Results According to our previous study,we selected13 miRNAs related to chemoresistance,and found that miR-744-5p was significantly upregulated in IMPC with paclitaxel resistance（ t =-2.650,p = 0.029）.After bioinfomatic analysis,CPFS4,Upf1 and PP2 A were detected to be potential target genes of miR-744-5p.Conclusion miR-744-5p may participate in regulation of paclitaxel resistance in IMPC,furthermore,it would be the promising biomarker of IMPC chemoresistance.
同期刊论文项目
同项目期刊论文
Role of ERRF, a Novel ER-Related Nuclear Factor, in the Growth Control of ER-Positive Human Breast C
The clinicopathological significance of CD44(+)/CD24(-/low) and CD24(+) tumor cells in invasive micr
Overexpression of ubiquitous mitochondrial creatine kinase (uMtCK) accelerates tumor growth by inhib
Genetic heterogeneity of HER2 in breast cancer: impact on HER2 testing and its clinicopathologic sig
CD146, an epithelial-mesenchymal transition inducer, is associated with triple-negative breast cance
Breast magnetic resonance imaging in patients with occult breast carcinoma: evaluation on feasibilit
Invasive Ductal Carcinoma with Osteoclastic Giant Cells of Breast: Clinicopathologic Characteristics
Tumor secretion of CCL22 activates intratumoral Treg infiltration and is independent prognostic pred
CD8(+) cytotoxic T cell and FOXP3(+) regulatory T cell infiltration in relation to breast cancer sur
Nipple Involvement in Breast Cancer: Retrospective Analysis of 2323 Consecutive Mastectomy Specimens
Deep sequencing reveals small RNA characterization of invasive micropapillary carcinomas of the brea
期刊信息
位置：