中文摘要：

基因调控网络（gene regulatory network,GRN）是用于研究基因调控的一种新兴的系统生物学方法,尤其适合描述生物体早期发育的调控系统和机制。由于它能体现出调控过程的网络特性和动态关系,从整体的角度全面审视环境扰动所造成的真实影响,因此有望在内分泌干扰物等环境污染物的发育毒性机制研究中发挥重要作用,解决多年来一直困扰相关研究的种种难题。针对基因调控网络的结构、研究方法、应用成果和案例进行综述,并对将这一方法应用于污染物发育毒性机制研究的前景做出展望。

英文摘要：

Gene regulatory network（GRN） was a novel systematical biology approach for the study on gene regulation mechanism,especially helpful in describing the early development of animal body.Because GRNs can present the networks and dynamics of regulatory processing,and the true impacts from the environmental perturbation,they were expected to play a key role in studying developmental toxicity mechanisms of environmental pollutants including endocrine disrupting chemicals with resolving many problems which existed for a long time.The structures,methodologies,current application cases of GRNs are rewiewed.The application of GRNs into mechanism researches of developmental toxicity of pollutants is previewed in this paper.