中文摘要：

目的：了解耐甲氧西林表皮葡萄球菌感染情况和耐药特点.方法：回顾性分析131株耐甲氧西林表皮葡萄球菌感染情况及耐药性特点.结果：在这2年期间耐甲氧西林表皮葡萄球菌（MRSE）检出率86.2%.科室分布以新生儿科为最多（20.6%）,58.8%（来源于伤口标本,25.2%来源于血液标本.按年份分组比较分析,MRSE检出率由89.4%降到83.7%;MRSE对克拉霉素、阿奇霉素、红霉素和复方新诺明的耐药性增强,对庆大霉素物、四环素、环丙沙星和克林霉素的耐药性降低,对万古霉素、利奈唑烷和替加环素均敏感.结论：表皮葡萄球菌感染以MRSE菌居多,MRSE对常用抗生素耐药性明显高于甲氧西林敏感葡萄球菌（MSSE）.其医院感染检出率降低,社区感染检出率升高.

英文摘要：

Objective：To investigate methicil- lin -resistant staphylococcus epidermidis （ MRSE ） infection and drug - resistance. Methods：The survey was conducted over a period of 24 months between Nov 2009 and Oct 2011 in our hospital. A total of 131 ca- ses of methicillin - resistant staphylococcus epidermidis infection were analysed and per- formed with drug sensitivity test. Results： The detection rate of MRSE among all the i- solated strains is 86. 2% （131/152） in our hospital during the two - year period. 20. 6% （27/131 ） from newborn department. 58.8% （77/131）is from wound specimens. 25.2% （33/131）is from blood specimens . the detection rate of MRSE decreased from 89.4% （59/66） to 83.7% （72/86）. Mean- while,the resistance rates of the MRSE to the antibiotics （ Sulfamethoxazole/Trime-thoprim clarithromycin, azithromycin, eryth- romycin） were increased,whereas for the an- tibiotics （ gentamiein, tetracycline, eiprofloxa- cin, levofloxacin, oxifloxacin, elindamycin ） the resistance rates were decreased. They were all sensitive to vancomyein, linezolid, tigecycline. Conclusion： Staphylococcus epi- dermidis infections are mostly MRSE bacte- ria. clindamyein, its antibiotic resistance to Common antibiotics was significantlyhigher than methieillin - sensitive staphylococcus. The Hospital infection rate of MRSE was decreased, at the same time, the community in- fection rate of MRSE was increased.