中文摘要：

肿瘤细胞表面sLe^a/x的表达水平与组织病理学参数正相关,且是转移性疾病的一个很重要的预后指标。sLe^a/x与其配体E-选择素的结合启动了肿瘤血源性转移的发生。sLe^a/x与其配体的相互作用需要一定的活性构象,而基于模拟sLe^a/x的生物活性结构而设计的一类小分子化合物,可以有效地抑制sLe^a/x与其配体的结合,从而发挥抗肿瘤作用。对sLe^a/x的分子结构、在人体内的生物合成、在人肿瘤组织中的分布,尤其是近年来sLe^a/x与肿瘤血源性转移关系的研究及以sLe^a/x为靶点的抗肿瘤药物的设计开发进行了综述。

英文摘要：

The expression of sLe^a/xwhich correlates with conventional histopathologic parameters serves as a useful indicator for the prognosis of metastatic disease. The bindings between sLe^a/x and their common ligand Eselectin initiate hematogenous metastasis of cancer. Certain bioactive conformation is crucial for the interaction between sLe^a/x and their ligands. Thus, a new class of compounds inhibit not only their functional bindings to selectins, but also the the sLe^a/x molecular structure, biosynthesis, distribution, e hematogenous metastasis of cancer and the design of drugs that mimic the structures of sLe^a/x.