东篱科研大数据发现系统（DRDS）

位置：成果数据库 > 期刊 > 期刊详情页

Polymorphisms of dihydropyrimidine dehydrogenase gene and clinical outcomes of gastric cancer patients treated with fluorouracil-based adjuvant chemotherapy in Chinese population

ISSN号：0366-6999
期刊名称：《中华医学杂志：英文版》
时间：0
分类：TQ463.54[化学工程—制药化工] Q346.5[生物学—遗传学]
作者机构：[1]Department of Hematology and OncologyZhongda Hospital,-Medica） School, SoutheastUniversity, Nanjing, Jiangsu 210009, China, [2]Department of GeneralSurgery zhongda Hospital, Medical School, SoutheastUniversity, Nanjing, Jiangsu 210009, China, [3]Department of~Oncology, Medical School, Southeast University,Nanjing, Jiangsu 210009, China, [4]National Key Laboratory for Bioelectronics, School of BiologicalScience and Medical Engineering, Southeast University, Nanjing,Jiangsu 210096, China, [5]Department of Epidemiology and Biostatistics, Nanjing MedicalUniversity, Nanjing, Jiangsu 210029, China
相关基金：This study was sponsored by the National Basic Research Program of China （973 Program, No. 2010CB732404）; Major project fund of the Science and Technology Department of Jiangsu province （No. EM2006111）; and the Southeast University Science and Technology fund （No. KJ2010494）.

作者： ZHANG Xiao-ping[1,3], BAI Zhi-bin[2,3], CHEN Bao-an[1,3], FENG Ji-feng[1], YAN Feng[1], JIANG Zhi[1], ZHONG Yue-jiao[1], WU Jian-zhong[1], CHEN Lu[3,4], LU Zu-hong[3,4], TONG Na[5], ZHANG Zheng-dong[5], XU-Pei-pei[3], PENG Miao-xin[3], ZHANG Wen-jing[3], WANG Shuai[3]

关键词：氟尿嘧啶, 基因多态性, 临床疗效, 中国人口, 脱氢酶, 二氢, 患者, 胃癌, gastric cancer, single nucleotide polymorphisms, dihydropyrimidine dehydrogenase, fluorouracil

中文摘要：

背景 Dihydropyrimidine 脱氢酶( DPD )，涉及5氟尿嘧啶( 5-FU )的分解代谢的关键酶，是关于这研究的 .The 目的是探索在 dihydropyrimidine 脱氢酶基因( DPYD )和在中国 population.Methods 与基于氟尿嘧啶的辅助化疗对待的胃的癌症病人的临床的结果的多型性之间的协会的 5-FU 的功效和毒性的 pharmacogenetic 研究的吸引人的候选人有气体的 362 个病人

英文摘要：

Background Dihydropyrimidine dehydrogenase （DPD）, a key enzyme involved in the catabolism of 5-fluorouracil （5-FU）, is the attractive candidate for pharmacogenetic research on efficacies and toxicities of 5-FU. The aim of this study is to explore the association between polymorphisms of dihydropyrimidine dehydrogenase gene （DPYD） and clinical outcomes of gastric cancer patients treated with fluorouracil-based adjuvant chemotherapy in the Chinese population.

同期刊论文项目