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Anticancer and multidrug-resistance reversing potential of traditional medicinal plants and their bioactive compounds in leukemia cell lines
  • ISSN号：2095-6975
  • 期刊名称：《中国天然药物：英文版》
  • 时间：0
  • 分类：R965[医药卫生—药理学;医药卫生—药学]
  • 作者机构：[1]Department of Neoplastic Hematologic Disorders (Medical Science Key Subject of Jiangsu Province), Zhongda Hospital, Schoool ofMedicine, Southeast University, Nanjing 210009, China, [2]Department of Oncology, School of Medicine, Southeast University, Nanjing 210009, China, [3]State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and lntervention, China PharmaceuticalUniversity, Nanjing 210009, China
  • 相关基金：This project was supported by the National Natural Science Foundation of ER. China （Nos. 81170492, 81370673）, National High Technology Research and Development Program 863 of ER. China （No. 2012AA022703）, National Key Basic Research Program 973 of ER. China （No. 2010CB732404）, Key Medical Projects of Jiangsu Province （No. BL2014078） and Key Discipline of Jiangsu Province （2011-2015）.
作者： Ravichandran Senthilkumar[1,2], CHEN Bao-An[1,2], CAI Xiao-Hui[1,2], FU Rong[3]
中文摘要：

Multidrug resistance remains a serious clinical problem in the successful therapy of malignant diseases. It occurs in cultured tumor cell lines, as well as in human cancers. Therefore, it is critical to develop novel anticancer drugs with multidrug-resistance modulating potential to increase the survival rate of leukemia patients. Plant-derived natural products have been used for the treatment of various diseases for thousands of years. This review summarizes the anticancer and multidrug-resistance reversing properties of the extracts and bioactive compounds from traditional medicinal plants in different leukemia cell lines. Further mechanistic studies will pave the road to establish the anticancer potential of plant-derived natural compounds.

英文摘要：

Multidrug resistance remains a serious clinical problem in the successful therapy of malignant diseases. It occurs in cultured tumor cell lines, as well as in human cancers. Therefore, it is critical to develop novel anticancer drugs with multidrug-resistance modulating potential to increase the survival rate of leukemia patients. Plant-derived natural products have been used for the treatment of various diseases for thousands of years. This review summarizes the anticancer and multidrug-resistance reversing properties of the extracts and bioactive compounds from traditional medicinal plants in different leukemia cell lines. Further mechanistic studies will pave the road to establish the anticancer potential of plant-derived natural compounds.

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期刊信息
  • 《中国天然药物：英文版》
  • 北大核心期刊（2008版）
  • 主管单位:中华人民共和国教育部
  • 主办单位:中国药科大学 中国药学会
  • 主编：吴晓明
  • 地址：南京童家巷24号中国药科大学2号信箱
  • 邮编：210009
  • 邮箱：cpucjnm@163.com
  • 电话：025-83271565 83271568
  • 国际标准刊号：ISSN：2095-6975
  • 国内统一刊号：ISSN：32-1845/R
  • 邮发代号:28-306
  • 获奖情况:
  • 国内外数据库收录:
  • 美国国际药学文摘,美国化学文摘（网络版）,波兰哥白尼索引,美国生物医学检索系统,美国科学引文索引（扩展库）,美国生物科学数据库,中国中国科技核心期刊,中国北大核心期刊（2008版）
  • 被引量:6564