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中文摘要：
ABCG2是A11P结合盒（ABC）转运超家族中的一员，其过表达被认为是限制多种化疗药物在细胞内聚集的重要机制之一。ABCG2底物范围广泛，包括多种抗肿瘤药物和环境致癌物等，与肿瘤的多药耐药（MDR）和肿瘤发展有关。以ABCG2为靶点逆转MDR受到广泛关注。
英文摘要：
ABCG2 is a member of the ATP-binding cassette （ABC） transporter family. The overex- pression of ABCG2 is identified as one of the important mechanisms that limiting cellular accumulation of vari- ous compounds. With regard to its broad substrate spectrum including various anticancer drugs and environmen- tal carcinogens, the function of ABCG2 is associated with muhidrug resistance （MDR） and tumor development. ABCG2 as a target site to reverse MDR has been widely concered.
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