中文摘要：

帕金森病是一种中、老年中枢神经系统退行性疾病,发病机制尚未明确。目前较认可的有遗传因素、环境因素、蛋白质表达异常、氧化应激、铁代谢异常、泛素-蛋白酶体系统及自噬等因素。现就以上几方面对近几年有关帕金森病发病机制的研究作一综述。

英文摘要：

Parkinson＇s disease （PD） is a common neurodegenerative disease in the central nervous system of middle and old aged people, of which the pathogenesis remains unclear so far. The possible factors are genetics factors, environmental factors, abnormal expression of protein, oxidative stress, abnormal metabolism of iron, the ubiquitin-proteasome system and autophagy. In this article the influencing factors based on several aspects mentioned above on the pathogenesis of Parkinson＇s disease in recent years are reviewed.