目的:观察小儿推拿对小儿哮喘不同时期IL-17、IL-33、IL-6水平变化影响。方法:将急性发作期、慢性持续期和缓解期哮喘婴儿100例,严格遵循随机分组的原则分为推拿组50例和哮喘组50例。哮喘组应用不同时期、不同基础治疗方式。推拿组在基础治疗的基础上,应用小儿推拿,两组各观察14天,在治疗前后取外周血,检测IL-17、IL-33、IL-6水平。结果:两组患儿检测急性发作期、慢性持续期,推拿组缓解期血清中IL-17、IL-33、IL-6水平,治疗后较治疗前明显下降(P〈0.05);急性发作期血清中IL一17水平,慢性持续期和缓解期治疗后推拿组血清中IL-17、IL-33、IL-6水平,与哮喘组比较有统计学差异(P〈0.05)。结论:小儿推拿手法可以通过降低血清中IL-17、IL-33、IL-6水平,来改善小儿哮喘的临床症状。
Objective: To investigate the effect of massage on IL - 17,IL - 33 and IL - 6 of pediatric asthma in different time. Methods: 100 patientg in different time were enrolled and divided into two groups randomly. The asthma group (50 cases) were trea- ted with different foundation treatment in different periods, while massage group (50 cases) applied pediatric massage on the basis of foun- dation treatment, both groups were observed for 14 days. All patients were assessed with IL - 17, IL -33 and IL -6 in serum at the begin- ning of the training and 14 days after treatment. Results: Two groups were detected in different times, the levels of IL - 17, IL -33 and IL - 6 in massage group were lower in remission stage after treatment than before treatment ( P 〈 0. 05 ) ; compared with asthma group, the level of IL - 17 in acute stage, the levels of IL - 17, IL - 33 and IL - 6 in chronic duration and remission stage, were significant different in massage group. Conclusion : Massage maybe improve the clinical symptoms of pediatric asthma by descending the levels of IL - 17, IL - 33 and IL- 6 in serum.